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| Value of endometrial cytology test combined with serum HE4 and CA724 levels for early diagnosing endometrial cancer |
| Changxing County Maternal and Child Health Care Hospital, Zhejiang Province, 31310 |
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Abstract To explore the value of endometrial cytology test (ECT) combined with serum human epididymal epithelial secretory protein 4 (HE4) and carbohydrate antigen 724 (CA724) levels for early diagnosing endometrial cancer. Methods: The clinic data of 80 patients with abnormal uterine bleeding, endometrial thickening, or abnormal echo in the uterine cavity by ultrasound examination From March 2019 to March 2021 were selected in this research. Pathological examination of these patients was carried out after ECT and diagnostic curettage. Enzyme-linked immunosorbent assay (ELISA) was performed to detect the levels of serum HE4 and CA724 of these patients. The diagnostic values of the serum HE4 and CA724 levels, and ECT for diagnosing endometrial cancer were evaluated. Results: There was no significant difference in the satisfaction of the samples of the patients between ECT and diagnostic curettage (P＞0.05), but the degree of pain and the blood loss of the patients with diagnostic curettage were significant higher (P<0.05). Among the 80 patients, 77 patients with the satisfactory samples for ECT were taken as the research target, there were 44 cases with endometrial cancer and 33 cases without endometrial cancer by ECT examination, and there were 43 cases with endometrial cancer and 34 cases without endometrial cancer by diagnostic curettage. The levels of serum HE4 and CA724 of the patients with endometrial cancer were significantly higher than those of the patients without endometrial cancer (P<0.05). The receiver operating characteristic curve analysis showed that the area under the curve (AUC) of the serum HE4 and CA724 levels for diagnosing endometrial cancer were 0.817 and 0.844, and the cut-off values of which were 74.442 pmol/L and 8.506 U/ml. The sensitivity, the specificity, and the accuracy of ECT combined with the serum HE4 and CA724 levels for diagnosing endometrial cancer were 90.7%, 91.2%, and 90.9%, respectively, and which were the highest. And the misdiagnosis rate and the missed diagnosis rate of ECT combined with the serum HE4 and CA724 levels for diagnosing endometrial cancer were 8.8% and 9.3%, and which were the lowest (P<0.05). Conclusion: Compared with those of diagnostic curettage, ECT has the advantages of less pain and less bleeding. The levels of serum HE4 and CA724 of the patients with endometrial cancer increase abnormally. The combination of ECT, HE4, and CA724 levels of the patients can improve their diagnostic efficacy for endometrial cancer, and which can be used as an aiding method for screening endometrial cancer.
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