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| Value of the levels of peripheral blood placenta specific protein 1 and tissue factor pathway inhibitor of pregnant women for predicting their severe preeclampsia |
| Wuxi Maternal and Child Health Care Hospital, Wuxi, Jiangsu Province, 214000 |
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Abstract To explore the value of the expression levels of peripheral blood placenta specific protein 1 (PLAC1) and tissue factor pathway inhibitor (TFPI) of pregnant women for predicting their severe preeclampsia. Methods: A total of 101 pregnant women with preeclampsia were enrolled in observation group between June 2018 and December 2020, which included 24 cases with severe preeclampsia. 100 normal pregnant women were enrolled in control group during the same period. The levels of PLAC1 and TFPI in peripheral blood of the women in the two groups were detected. Results: The PLAC1 level in peripheral blood (3.35±0.74ng/ml) of the women in the observation group was significantly lower than that (4.12±1.29ng/ml) of the women in the control group. The level of TFPI (47.29±7.16ng/ml) of the women in the observation group was significantly higher than that (35.37±5.82ng/ml) of the women in the control group. The PLAC1 level in peripheral blood (2.87±0.52 ng/ml) of the women with severe preeclampsia was significantly lower than that (3.50±0.79 ng/ml) of the women with preeclampsia，and the level of TFPI (52.94±8.56ng/ml) of the women with severe preeclampsia was significantly higher than that (45.53±6.32ng/ml) of the women with preeclampsia (all P<0.05). Receiver operating characteristic curve analysis showed that the area under the curve, the sensitivity, and the specificity of the combined the PLAC1 and TFPI levels for predicting severe preeclampsia were 0.840, 83.3%, and 71.4%, respectively, and the predictive efficiency of which was significantly higher than that of the PLAC1 level of TFPI level alone (P<0.05). Conclusion: The level of PLAC1 in peripheral blood of the pregnant women with severe preeclampsia decreases, while their TFPI level increases. The combined detection of the PLAC1 and TFPI levels for predicting severe preeclampsia has certain guidance value in clinic.
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