To analyze the clinical pathological characteristics and survival status of patients with endometrial carcinoma(EC), and to explore the correlation between the clinical pathological characteristics of these patients and their survival status. Methods: The clinical data of 112 patients with EC from January 2010 to May 2015 were collected, and the survival conditions of the patients were followed up for 1, 3, and 5 years. According to the survival time of the patients, these patients were divided in to group A(patients with survival time ≥3 years) and group B(patients with survival time＜3 years), and the clinical pathological characteristics of the patients were compared between the two groups. The Cox regression model was used to analyze the correlation between the clinical pathological characteristics of the patients and their survival status. Results: The median survival time of 112 patients with EC after follow-up was 42 months(1-88 months). The survival rates of 112 patients with EC after 1 year, 3 years, and 5 years were 92.0%, 79.5%, and 72.3%, respectively. There were 89 patients in group A and 23 patients in group B. There were significant differences in the age, the pathological type, the degree of tumor differentiation, the tumor size, the FIGO stage, the muscular invasion rate, the lymph node metastasis and lymphatic vascular invasion situations, and the expressions of ER and PR of the patients between the two groups(P<0.05). There was no significant difference in the menopause situation, the surgical methods, and the adjuvant therapy methods of the patients between the two groups(P>0.05). Cox regression model showed that the pathological type, the tumor differentiation degree, the tumor FIGO stage, the lymph node metastasis, the ER expression and PR expression were the independent risk factors of the survival status of the patients with EC(P<0.05). Conclusion: The patients with EC type II, tumor undifferentiated/poorly differentiated, FIGO stage III-IV, lymph node metastasis, or positive ER and PR expression have poor survival condition after operation. Therefore, enough attention should be paid to the patients with risk factors of clinical and pathological characteristics of EC.