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| Efficacy of low molecular weight heparin calcium for adjuvant treating women with recurrent abortion and its effects on their cyclooxygenase 2 and interleukin 33 levels |
| Anyang Maternal and Child Health Care Hospital, Anyang, Henan Province, 455000 |
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Abstract To study the efficacy of low molecular weight heparin calcium for adjuvant treating women with recurrent abortion, and to study its effects on their cyclooxygenase 2(COX-2) and interleukin 33(IL-33) levels. Methods: 121 women with recurrent abortion were selected and were divided into two groups by random number table method from January 2019 to January 2021. 61 women in the study group were given aspirin combined with low molecular weight heparin calcium treatment, and 60 women in the control group were given aspirin only. The clinical efficacy, the changes of the levels of serum COX-2, IL-33, estradiol(E2), progesterone(P), chorionic gonadotropin(β-HCG), and D-dimer(D-D), the plasminogen activator inhibitor 1(PAI-1) and fibrinogen levels, and the incidence of adverse reactions of the women were compared between the two groups. Results: After treatment, the total effective rate(83.6%) of the women in the study group was significantly higher than that(66.7%) of the women in the control group. The serum levels of COX-2 and IL-33(525.47±67.19 U/L and 1318.15±398.61 ng/L) of the women in the study group were significantly higher than those of the women(444.94±76.05U/L and 1017.79±150.16 ng/L) in the control group. The serum E2, P, and β-hCG levels of the women in both groups had increased significantly, and which of the women in the study group was significantly higher than that of the women in the control group. The serum levels of D-D, PAI-1, and fibrinogen of the women in the two groups had decreased significantly, and which(121.34±26.55μg/L, 0.51±0.23 AU/ml, and 2.13±0.24 g/L) of the women in the study group were significantly lower than those(187.97±35.23μg/L, 0.95±0.28 AU/ml, and 4.11±0.35 g/L) of the women in the control group(all P<0.05). There was no significant difference in the total incidence of adverse reactions(8.2% vs. 11.7%) of the women between the two groups(P>0.05). Conclusion: Low molecular weight heparin calcium as adjuvant therapy for the women with recurrent abortion can improve the effect with good safety, which may be related to the effectively improvement of COX-2 and IL-33 levels.
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