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| Effect of Guizhi fuling capsule for treating women with endometriosis and its influence on their expression levels of serum fetal liver kinase-1, cyclooxygenase-2, vascular endothelial growth factor, and prostaglandin 2 |
| The General Hospital of the Eastern Theater of the Chinese People's Liberation Army, Nanjing, Jiangsu Province, 210000 |
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Abstract To observe the expression levels of of serum fetal liver kinase-1(Flk-1), cyclooxygenase-2(COX-2), vascular endothelial growth factor(VEGF), and prostaglandin 2(PGE2) of women with endometriosis(EMs), and to study the effect of Guizhi fuling capsule for treating these patients. Methods: 126 women with EMs were selected and were randomly divided in group A and group B from January 2020 to January 2021. 63 women in group A had received conventional treatment for 3 months, and 63 women in group B had received conventional treatment combined with Guizhi fuling capsules for 3 months. Another 40 women who received healthy physical examination were selected in group C during the same period. The levels of serum Flk-1, COX-2, VEGF, and PGE2 of the women in the three groups were detected. The women in group A and B were given reexamination after treatment for evaluating their lesion area of Ems. Numerical rating scale(NRS) score and Chinese 30 version of Endometriosis Health Profile-30(EHP-30) score were conducted in group A and B. Results: The serum levels of FLK-1(29.72±6.14 ng/ml), COX-2(16.59±3.42 ng/ml), VEGF(183.02±40.17 pg/ml), and PGE2(589.74±56.33 pg/ml) of the women in group A and group B were significantly higher than those(9.02±1.13 ng/ml, 5.45±1.38 ng/ml, 58.52±14.37 pg/ml, and 105.63±14.59 pg/ml) of the women in group C, and which of the women with r-AFS Ⅲ-Ⅳ stage of EMs were significantly higher than those of the women with r-AFS Ⅰ-Ⅱstage of EMs, and which were positively correlated with the r-AFS stage(all P<0.05). After treatment, the lesion area(5.08±1.33 cm2), NRS score(1.69±0.34 points), and EHP-30 score(16.58±1.89 points) of the women in group A were significantly lower than those(6.31±1.25 cm2, 3.01±0.59 points, and 22.13±2.69 points) of the women in group B. The serum levels of FLK-1, COX-2, VEGF, and PGE2 of the women in group A were significantly lower than those of the women in group B. The total effective rate(96.8%) of the women in group A was significantly higher than that(85.7%) of the women in group B. The efficacy of the women with r-AFS Ⅲ-Ⅳ stage of EMs in group A was significantly better than that of the women with r-AFS Ⅲ-Ⅳ stage of EMs in group B(all P<0.05). There was no significant difference in the adverse reactions rate of the women between group A and group B. Conclusion: The expressions of serum Flk-1, COX-2, VEGF, and PGE2 of the women with EMs increase abnormally, which are closely related to the clinical stage of EMs. Guizhi fuling capsule for treating the women with EMs has efficacy by down-regulating their levels of Flk-1, COX-2, VEGF, and PGE2.
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