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| Serum feeding inhibitor-1 and neural axon guidance factor-1 expression levels of women with endometriosis and their correlation with the clinical symptoms |
| Dalian Women and Children's Medical Center (Group), Dalian, Liaoning Province, 116033 |
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Abstract To investigate the expression levels of serum feeding inhibitor-1 (nesfatin-1) and neural axon guidance factor-1 (netrin-1) of women with endometriosis, and to study their correlation with the clinical symptoms of the women. Methods: A total of 112 women with endometriosis were selected in study group and 50 healthy women with similar age were selected in control group from June 2018 to May 2020. Enzyme-linked immunosorbent double antibody sandwich method was used to detect the levels of serum nesfatin-1 and netrin-1 of the women in the two groups. Receiver operating characteristic (ROC) curve was drawn to determine the cut-off values of the serum nesfatin-1 and netrin-1 levels of the women in the study group. The women were divided into different groups according to the cut-off values of the levels of serum nesfatin-1 and netrin-1 of the women. The relationship between the serum nesfatin-1 and netrin-1 levels of the women and their clinical symptoms of endometriosis was analyzed by Pearson correlation analysis. Results: The levels of serum nesfatin-1 (1.10±0.20μg/L)and netrin-1 (36.52±6.20 pg/ml) of the women in the study group were significantly lower than those (1.84±0.53μg/L and 165.85±15.63 pg/ml) of the women in the control group (all P＜0.05). According to ROC curve, the optimal cut-off values of serum nesfatin-1 and Netrin-1 levels of the women for diagnosing their endometriosis were 1.52μg/L and 95.6pg/ml, respectively. The scores of dysmenorrhea, pelvic pain, pain during intercourse, anal distension and other clinical symptoms of the women with ≤1.52 level of nesfatin-1 (89 cases) and the women with≤95.6 level of netrin-1 (82 cases) were all significantly higher than those of the women with >1.52 level of nesfatin-1 (23cases) and the women with >95.6 level of netrin-1 (30 cases)(all P＜0.05). The serum levels of nesfatin-1 and netrin-1 of the women with endometriosis were negatively correlated with their clinical symptoms of endometriosis (r=-0.324,-0.314, all P＜0.05). Conclusion: The levels of serum nesfatin-1 and netrin-1 of the women with endometriosis are abnormally low, and which are negatively correlated with their clinical symptoms of endometriosis. It is suggested that both serum nesfatin-1 and netrin-1 can be used as indicators to diagnosing endometriosis in clinic.
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