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| Predictive value of uterine artery parameters by ultrasonography combined with sex hormone levels of women during the second trimester of pregnancy for their late-onset fetal growth restriction |
| Hainan Women and Children Medical Center, Haikou, Hainan Province, 570206 |
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Abstract To explore the clinical value of uterine artery parameters by ultrasonography combined with sex hormone detective levels of pregnant women during the second trimester of pregnancy for predicting their late-onset fetal growth restriction (LO-FGR). Methods: The clinical data of 68 pregnant women with LO-FGR in observation group from January 2019 to July 2020 and another 68 healthy pregnant women in control group who received regular antenatal examination during the same period were analyzed retrospectively. The uterine artery parameters of the women during 25-27 gestational weeks in the two groups were examined by ultrasonography, and the values of the pulsatile index (PI), resistance index (RI), and systolic peak velocity/diastolic velocity (S/D) of the uterine artery of the women were recorded. The levels of serum free estriol (FE3) and progesterone (P) of the women in the two groups were detected. The values of the uterine artery parameters by ultrasound and the sex hormones levels for predicting LO-FGR were analyzed. Results: There were significant differences in the values of PI (0.77±0.21 vs. 0.60±0.17), RI (0.50±0.19 vs.0.42±0.14), and S/D (2.04±0.77 vs.1.62±0.54), and the levels of serum FE3 (16.33±1.89 nmol/L vs.25.69±3.27 nmol/L) and P (14.72±3.85 ng/ml vs.24.66±5.02ng/ml) of the women between the two groups (all P＜0.05). Receiver operator characteristic (ROC) curve analysis showed that the area under curve (AUC) of uterine artery parameters for predicting LO-FGR was 0.783 (95%CI: 0.621-0.822), with the sensitivity of 79.8% and the specificity of 69.8%. When the optimal cut-off value of serum FE3 level was 17.27 nmol/l, the AUC of which for predicting LO-FGR was 0.606 (95%CI: 0.506-0.709), with the sensitivity of 68.3% and the specificity of 65.2%. When the optimal cut-off value of serum P level was 15.69 ng/ml, the AUC of which for predicting LO-FGR was 0.624 (95%CI: 0.510-0.724), with the sensitivity of 70.0% and the specificity of 59.9%. The AUC, the sensitivity, and the specificity of the uterine artery parameters values combined with the levels of serum FE3 and P for predicting LO-FGR were 0.902, 90.3%, and 91.3%, respectively. Conclusion: The ultrasonic blood flow parameters of uterine artery and the levels of FE3 and P of the pregnant women with LO-FGR are abnormal changes. The combinations of ultrasonic blood flow parameters of uterine artery combined with the levels of FE3 and P of the pregnant women have better value for predicting their LO-FGR.
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