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| Correlation between the values of blood flow parameters of cervical cancer tissue by Doppler ultrasound of the patients and their serum matrix metalloproteinase-2 expression level |
| Beijing Road Medical District, General Hospital of Xinjiang Military Region, Urumqi, Xinjiang, 830013 |
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Abstract To detect the values of blood flow parameters of cervical cancer tissue by Doppler ultrasound and the expression level of matrix metalloproteinase-2 (MMP-2) of the patients, to study the correlation between the values of blood flow parameters of cervical cancer tissue of the patients and their serum MMP-2 level, and to analyze their value for diagnosing cervical cancer. Methods: A total of 83 patients with cervical cancer confirmed by pathology were selected in group A, and 70 patients with cervical cancer epithelial neoplasia (CIN) were selected in group B from October 2016 to October 2019. Meanwhile, 70 patients with benign uterine lesions were selected in group C. The values of peak systolic velocity (PSV) and resistance index (RI) of lesion tissue of the patients in the three groups were examined by Doppler ultrasound. The level of serum MMP-2 of the patients in the three groups was detected by enzyme-linked immunosorbent assay. The patients in group A were further divided into group A1 (29 cases with stage I), group A2 (25 cases with stage II), and group A3 (16 cases with stage III) according to FIGO stage of cervical cancer, and the value of PSV and RI, and the serum MMP-2 level of the patients were compared among the three groups. Pearson method was used to analyze the correlation between the serum MMP-2 level of the patients with cervical cancer and their PSV and RI values. Receiver operator characteristic (ROC) curve was used to analyze the diagnostic efficacy of the PSV and RI values, and the serum MMP-2 level of the patients for their cervical cancer. Results: The PSV value and MMP-2 level of the patients in group C, group B, and group A had increased gradually, while the value of RI of the patients had decreased gradually. The PSV value and MMP-2 level of the patients in group A1, group A2, and group A3 had increased gradually, while the value of RI of the patients had decreased gradually (all P＜0.05). The serum MMP-2 level of the patients with cervical cancer was positively correlated with their PSV value (r=0.690, P＜0.05), but which was negatively correlated with their RI value (r=-0.516, P＜0.05). ROC analysis showed that as for diagnosing cervical cancer, the value of PSV was 0.783, the value of RI was 0.777, the value of PSV combined with RI was 0.864, the value of serum MMP-2 was 0.883. The diagnostic value of serum MMP-2 for cervical cancer was significantly higher than that of PSV of RI alone (P＜0.05), but which had no significant different from that of the values of PSV combined with RI (P>0.05). Conclusion: The PSV value and serum MMP-2 level of the patients with cervical cancer increase, while their RI value decreases. The combined detection of the PSV and RI values by Doppler ultrasound and the serum MMP-2 level of the patients had certain value for diagnosing their cervical cancer. It is suggested that the MMP-2 level maybe replace blood flow parameters by Doppler ultrasound for diagnosing cervical cancer to a certain extent, which can be used as a serological indicator to differentiate cervical cancer from cervical precancerous lesions.
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