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| Clinical efficacy of cervical loop electrosurgical excision procedure for treating patients with cervical squamous intraepithelial lesions who wanted fertilitypreserving and their subseguent pregnancy outcomes |
| The Third Affiliated Hospital of Chengdu Medical College, The People's Hospital of Pidu District, Chengdu, Sichuan Province, 611730 |
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Abstract To explore the clinical efficacy of cervical loop electrosurgical excision procedure (LEEP) for treating patients with squamous intraepithelial lesions who wanted fertility-preserving, and to study the postoperative pregnancy outcomes of these patients. Methods: 159 patients with cervical squamous intraepithelial lesions who wanted fertility-preserving from June 2014 to June 2019 were collected and were divided in group A (81 patients with LEEP) and group B (78 patients with cold knife cervical conical resection) according to different surgical methods. The surgical status, the postoperative complications, the recurrence of the cervical squamous intraepithelial lesions, the postoperative pregnancy outcomes and delivery model of the patients were compared between the two groups. Results: The operative time (10.69±2.26min), the intraoperative blood loss (12.36±1.06ml), the healing time (27.39±4.68d), and the time of hospital stay (4.25±1.33d) of the patients in group A were significantly less than those of the patients in group B. The total incidence of postoperative complications (9.9%) of the patients in group A was significantly lower than that (21.9%) of the patients in group B. The recurrence rate of the cervical squamous intraepithelial lesions (9.0%) of the patients within 1 year after surgery in group A was significantly higher than that (1.2%) of the patients in group B (P＜0.05). There were no significant differences in the rates of the abortion, the full-term birth, and the ectopic pregnancy of the patients with postoperative pregnancy between the two groups (P>0.05). The duration of labor, the premature delivery rate, and the premature rupture rate of membranes of the patients with postoperative pregnancy in group A were significantly lower than those of the patients in group B, and the newborn body weight of the patients with postoperative pregnancy in group A was significantly higher than that of the patients in group B (P＜0.05). There was no significant difference in delivery model of the postoperative pregnancy of the patients between the two groups (P>0.05). Conclusion: As for the patients with high-grade squamous intraepithelial lesions of the cervix who need to preserve fertility, LEEP treatment has exact effectiveness, which can effectively reduce the damage to their cervical tissue, help their recovery after surgery, and can improve their subseguent pregnancy outcomes, with lower incidence of postoperative complications.
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