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Abstract To analyze the recurrence situation of uterine fibroids, the levels of perioperative sex hormones, functional peptides, and small non-coding RNA of patients in different follow-up periods after hysteroscopic hysteromyomectomy, and to study their predictive value for the recurrence of uterine fibroids. Methods: 135 patients with uterine fibroids who had undergone hysteroscopic hysteromyomectomy and successfully completed 6 and 12 months of follow-up were selected in this study from December 2018 to December 2020. The levels of functional peptides and small non-coding RNA in uterine fibroids tissues, and the serum sex hormones levels of these patients were detected. The recurrence situations of uterine fibroids of these patients were evaluated in the 6th and in the 12th month of followed up, and these patients were divided two groups based on whether recurrence of uterine fibroids. The levels of functional peptides and small noncoding RNA in uterine fibroids tissues, and serum sex hormones levels of the patients were compared between the two groups. The values of the levels of functional peptides and small non-coding RNA in uterine fibroids tissues, and the serum sex hormones of the patients for predicting their recurrences of uterine fibroids in different time periods after hysteroscopic surgery were analyzed. Results: The recurrence rates of uterine fibroids of the patients in the 6th month and in the 12th month after surgery were 1.5% and 3.7%. The predictive value of the levels of functional peptides and small non-coding RNA in uterine fibroids tissues, and the serum sex hormones of the patients for their recurrence of uterine fibroids in 6 months of follow-up was low, and all the AUC of which were <0.8. The level of serum estradiol, progesterone, follicle stimulating hormone, functional peptides ANG-2, CTGF, or CA125 of the patients for predicting their recurrence of uterine fibroids in the 12th month after sugary had certain value, with the AUC of 0.800, 0.821, 0.801, 0.806, 0.833, or 0.807, respectively, and with the diagnostic critical value of 176.40ng/L, 0.64μg/L, 6.05IU/L, 303.73ng/L, 173.98μg/L, or 21.88IU/ml, respectively. The positive expressions of MCM7 and miR-18a had not shown the higher predictive diagnostic value. Conclusion: The levels of serum estradiol, progesterone, follicle stimulating hormone, and functional peptides Ang-2 and CTGF in uterine fibroids tissues, and CA125 of the patients with uterine fibroids have certain predictive diagnostic values for the recurrence of uterine fibroids in 12 months after hysteroscopic surgery, and the prevention and intervention should be carried out based on the diagnostic critical value of which of the patients in clinic.
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