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| Analysis of factors influencing premature rupture of membranes of pregnant women after conization of cervix |
| 1. Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, 524023; 2. Yiling District Maternal and Child Health Care Hospital, Yichang, Hubei Province |
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Abstract To analyze the factors influencing premature rupture of membranes (PROM) of pregnant women after conization of cervix. Methods: From March 2016 to September 2020, 192 pregnant women who had undergone conization of cervix were selected as the research objects, which included 52 cases with PROM in study group and 140 cases without PROM in control group. Among women in the study group, there were 13 cases with preterm premature rupture of membranes (PPROM) in group A and 39 cases with PROM after full term in group B. The age, the body mass index (BMI) during pregnancy, and the surgery method of conization of cervix of these women were recorded. The length of cervix（CL) of these women during 20-24 gestational weeks was measured by transvaginal ultrasound. Results: The age, the BMI value before pregnancy, the proportions of conization of cervix by cold knife conical (CKC) and pregnancy within 6-12 months after conization of cervix of the women in the study group were significantly higher than those of the women in the control group, the CL value of the women in the study group was significantly less than that of the women in the control group (all P<0.05). There were no significant differences in the proportions of pluripara and the pregnancy by assisted reproduction, and the types of cervical lesions of the women between the study group and the control group (P>0.05). The Age, the BMI value before pregnancy, surgery by CKC, and pregnancy within 6-12 months after surgery were the independent risk factors of PROM occurrence (P<0.05), and the CL was the independent protective factor of PROM occurrence (P<0.05). The age, and the proportions of surgery by CKC and pregnancy within 6-12 months after surgery of the women in group A were significantly higher than those of the women in group B, but the CL value of the women in group A was significantly lower than that of the women in group B (all P<0.05). There were no significant differences in the BMI value before pregnancy, the proportions of pluripara and the pregnancy by assisted reproduction, and the types of cervical lesions of the women between group A and group B (P>0.05). The CL was the independent protective factor of PPROM occurrence (P<0.05). The optimal truncation value of the age, the BMI value before pregnancy, and the CL value of the women for predicting their PROM were 36 years old, 25.4kg/m2, and 25.1mm, respectively. The optimal truncation value of the CL of the women for predicting their PPROM was 23.6mm. Conclusion: The advanced age, the obesity before pregnancy, and the short CL during the second trimester of pregnancy of the women are the risk factors of their PROM occurrence during pregnancy after conization of cervix.
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