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Abstract To explore the levels and the interaction of the serum heat shock protein 70 (HSP70), follicle stimulating hormone (FSH), and lutein hormone (LH) of the infertility women with polycystic ovarian syndrome (PCOS), and to study the correlation between the levels HSP70, FSH, and LH of the women with PCOS and their lipid metabolism. Methods: 106 women with PCOS who had been diagnosed during the first time visited hospital were selected in study group, and 50 healthy women of childbearing age who had been given physical examination were selected in control group from January 2018 to January 2021. The levels of HSP70, FSH, LH, total cholesterol (TC), low density lipoprotein (LDL), triglycerides (TG), high density lipoprotein (HDL), apolipoprotein A-1 (apoA-1), and apolipoprotein B-100 (apoB-100) of the women in the two groups were detected. The interaction of the serum HSP70, FSH, and LH of the women, and the relationship between the levels HSP70, FSH, and LH of the women with PCOS and their lipid metabolism disorder were analyzed. Results: The levels of the serum HSP70, FSH, LH, TC, TG, and LDL-C of the women in the study group were significantly higher than those of the women in the control group, but the levels of the HDL-C, apoA-1, and apoB-100 of the women in the study group were significantly lower (all P<0.05). There was interaction among the HSP70, FSH, and LH of the women (△R2=0.663, P=0.000). Person correlation analysis showed that the HSP70 level of the women was positively correlated with their TG level (r=0.177) and was negatively correlated with their APOA-1 (r=-0.143). The FSH level of the women was positively correlated with their TG and LDL-C levels (r=0.307, 0.193). There was a positive correlation between the LH level of the women and their TC level, TG level, or LDL-C level (r=0.167, 0.354, or 0.246), and the LH level of the women was negatively correlated with their HDL-C level or APOB-100 level (r=-0.144 or -0.167, all P<0.05). Conclusion: The levels of serum HSP70, FSH, LH, TC, TG, and LDL-C of the infertile women with PCOS increase, but the levels of their serum HDL-C, apoa-1 and apoB-100 decrease. There are interactions among the levels of HSP70, FSH, and LH of the women. The levels of serum HSP70, FSH, and LH of the infertile women with PCOS have certain correlation with their disorder of lipid metabolism.
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