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| Correlation between subclinical hypothyroidism of pregnant women during the first trimester of pregnancy and their pregnancy complications, their pregnancy outcomes, and the mental and motor development of their infants |
| 1. Beijing Road Medical District, General Hospital of Xinjiang Military Region, Urumqi, Xinjiang, 830026; 2. The Fifth Affiliated Hospital of Xinjiang Medical University |
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Abstract To analyze the correlation between subclinical hypothyroidism of pregnant women during the first trimester of pregnancy and their pregnancy complications, their pregnancy outcomes, and the mental and motor development of their infants with different corrected months of age. Methods: A total of 53 pregnant women with subclinical hypothyroidism during the first trimester of pregnancy were selected in study group from March 2020 to March 2021. 60 normal pregnant women were selected in control group during the same period. The offspring development situations of the women in the two groups after delivery had been corrected till the age of 14 months. The pregnancy complications and the pregnancy outcomes of the women, the newborn situation, and the mental and motor development of the infants with different corrected age of months were compared between the two groups. Spearman correlation analysis was used to analyze the correlation between the subclinical hypothyroidism of the women during the first trimester of pregnancy and their pregnancy complications, their pregnancy outcomes, their newborn situation, and the mental and motor development of their infants. Results: There was no significant difference in the pregnancy complications of the women between the two groups (P>0.05). The rates of the intrauterine fetal distress, the fetal growth restriction, the premature rupture of membranes, and the premature delivery of the women in the study group were significantly higher than those of the women in the control group (P<0.05). The MDI scores of the infants had significantly difference between G stage (6 months, 16 days to 8 months, 30 days) and I stage (11 months, 0 day to 13 months, 15 days). The PDI scores of the infants had significantly difference among D stage (3 months, 16 days to 4 months, 15 days), G stage, and I stage (all P<0.05). Spearman correlation analysis showed that the correlation coefficients between the subclinical hypothyroidism of the women during the first trimester of pregnancy and their pregnancy complications, their pregnancy outcomes, and the mental and motor development of their infants were all <0.3, which was weakly correlated (P<0.05). Conclusion: Subclinical hypothyroidism of the women during the first trimester of pregnancy can increase the incidences of fetal distress, growth restriction, premature rupture of membranes, and premature delivery, which also increase the risk of the mental development delay of the infants after corrected in 6-14 months of age and the motor development delay of the infants after corrected in 0-14 months of age. Although there is weak correlation between the subclinical hypothyroidism of the women during the first trimester of pregnancy and their pregnancy complications, their pregnancy outcomes, and the mental and motor development of their infants, attention should be paid in clinic.
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