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| Effect of nifedipine combined with labetalol for treating women with hypertension during pregnancy, and its influence on their serum adiponectin level and blood viscosity |
| Huaibei Maternal and Child Health Care Hospital, Anhui Province, 235000 |
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Abstract To explore the effect of nifedipine combined with labetalol for treating pregnant women with hypertension during pregnancy, and to study its influence on the serum adiponectin level and blood viscosity of the women. Methods: A total of 60 pregnant women with hypertension during pregnancy were selected and were randomly divided into two groups (30 cases in each group) from October 2019 to May 2021. The women in the control group were treated with labetalol, and the women in the observation group were treated with nifedipine combined with labetalol. The blood viscosity situation, the blood urea nitrogen level, the 24h urine protein quantification value, the serum adiponectin level, the high-sensitivity C-reactive protein (hs-CRP) level, the leucine aminopeptidase (LAP) level, the clinical efficacy, and the incidence of adverse reactions of the women were compared between the two groups. Results: The blood viscosity, the levels of serum urea nitrogen, hs-CRP, 24h urine protein quantitation, and the values of diastolic blood pressure and systolic blood pressure of the women in the two groups after treatment had decreased significantly, and which of the women in the observation group were significantly lower than those of the women in the control group. The levels of serum adiponectin and LAP of the women in the two groups after treatment had increased significantly, and which of the women in the observation group were significantly higher than those of the women in the control group (all P<0.05). The clinical efficacy (90.0%) of the women in the observation group was significantly higher than that (63.3%) of the women in the control group (P<0.05). There was no significant difference in the total incidence (30.0% vs. 13.3%), such as loss of appetite, lower extremity edema, dizziness and fatigue, of the women between the two groups (P>0.05). Conclusion: Nifedipine combined with labetalol in the treatment of hypertension during pregnancy of the women can effectively regulate their blood viscosity, reduce their inflammation response, increase their serum adiponectin and LAP levels, reduce their vascular endothelial damage, and improve their safe and effective of clinical treatment.
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