To observe the effect of labetalol combined with benazepril for treating early onset severe preeclampsia of pregnant women, and to study their influences on the levels of nuclear factor kappa-B (NF - κB) and pentaxin 3 (PTX3), and the perinatal outcome of the women. Methods: 110 pregnant women with early onset severe preeclampsiaon were selected prospectively and were divided into two groups by random number table from January 2018 to December 2020. The women in the control group were treated with benazepril, and the women in the study group were treated with benazepril combined with labetalol. The women in both groups were treated until 1 day before termination of pregnancy. The blood pressure value, and the levels of biochemical indexes, NF-κB, and PTX3, the rate of adverse reactions, and the perinatal outcomes of the women were compared between the two groups. Results: The values of blood pressure of the women in both groups had improved significantly, and the values of systolic and diastolic blood pressure (133.4±12.9 mmHg and 77.1±8.4 mmHg) of the women in the study group were significantly lower than those (140.6±13.6mmHg and 84.6±9.7 mmHg) of the women in the control group. The levels of blood uric acid and fasting blood glucose of the women in the study group were significantly lower than those of the women in the control group, but the level of serum potassium of the women in the study group was significantly higher. The levels of NF-κB and PTX3 of the women in both groups had decreased significantly, but which (7.68±2.09g/L and 1.88±0.32g/L) of the women in the study group were significantly lower than those (8.79±2.52g/L and 2.37±0.44g/L) of the women in the control group (all P<0.05). The incidence of adverse reactions (5.4%) of the women in study group was significantly lower than that (18.2%) of the women in the control group, the rate of postpartum complications (3.6%) of the women in study group was significantly lower than that (16.4%) of the women in the control group, and the incidence of the neonatal adverse events (3.6%) in the study group was lower than that (16.4%) in the control group (all P<0.05). Conclusion: Labetalol combined with benazepril for treating pregnant women with early onset severe preeclampsia for can not only improve their blood pressure and biochemical indexes, but also can significantly reduce their medication complications of pregnant women and improve their perinatal outcomes.