To observe the curative effect of lymphocyte active immunotherapy (LIT) combined with Yunkang oral solution for treating patients with alloimmune recurrent spontaneous abortion (RSA), and to explore its possible mechanism. Methods: 142 patients with alloimmune RSA were selected and randomly divided into observation group (n=73) and control group (n=69) from January 2019 to May 2020. The patients in the control group had received LIT, and the patients in the observation group had received Yunkang oral solution combined with LIT. The pregnancy conditions of the patients were compared between the two groups. The levels of helper T cells (Th) 1/Th2, Th17/regulatory T cells (Treg) of the patients in the two groups before and after treatment were detected, and the serum levels of Th1 cytokines, such as γ interferon (IFN-γ) and interleukin-2 (IL-2), Th2 cytokines, such as interleukin-4 (IL-4) and IL-6, Th17 cytokine, such as interleukin-17A (IL-17A) and interleukin-22 (IL-22), and Treg cytokines, such as transforming growth factor-β (TGF-β) and  IL-10, of the patients in the two groups were also detected. Results: The success rate of pregnancy of the patients in the observation group (87.7%) was significantly higher than that (73.9%) of the patients in the control group, and the preterm birth rate after successful pregnancy of the patients in the observation group (6.3%) was significantly lower than that (19.6%) of the patients in the control group (all P<0.05). After treatment, the levels of Th1 cells, and its cytokines IL-2, and IFN-γof the patients in the observation group were significantly lower than those of the patients in the control group, while the levels of Th2 cell and its cytokines IL-4 and IL-6 of the patients in the observation group were significantly higher than those of the patients in the control group. After treatment, the levels of Th17 and its cytokines IL-17A and IL-22 of the patients in the observation group were significantly lower than those of the patients in the control group, the levels of Treg and its cytokines TGF-β and IL-10 of the patients in the observation group were significantly higher, and the values of Th1/Th2, Th17/ Treg, IFN-γ/IL-4, and IL-17A/IL-10 of the patients in the observation group were significantly lower (all P<0.05). Conclusion: Yunkang oral solution combined with LIT for treating the patients with alloimmune RSA can improve their curative effect, which can improve the imbalance of Th1/Th2/Th17/Treg cells and the related cytokines of the patients, and can increase the success rate of pregnancy and decrease the preterm birth rate of the patients.