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| Correlation between the coagulation indexes of pregnant women with preeclampsia and their thrombelastogram parameters and their predictive value for adverse pregnancy outcomes of the women |
| 1. Zaozhuang Maternal and Child Health Care Hospital, Shandong Province, 277000; 2. Zaozhuang Vocational College, Shandong Province |
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Abstract To analyze the correlation between the thrombelastogram (TEG) parameters of pregnant women with preeclampsia (PE) and their thrombotic indicators, and to evaluate their predictive value for adverse pregnancy outcomes of these women. Methods: A total of 103 pregnant women with PE (in study group) and 50 normal pregnant women (in control group) were selected as study subjects from March 2018 to June 2020. The women in the study group were further divided into group A (75 cases with mild PE) and group B (28 cases with severe PE). The TEG parameters and the coagulation indexes of the women in these groups were detected and the differences of which of the women were compared among these groups. The correlation between the TEG parameters and the coagulation indexes was analyzed. The predictive value of TEG parameters for adverse pregnancy outcomes of the women was analyzed by receiver operator characteristic (ROC) curve. Results: The values of R and K of the women in group A and in group B were significantly lower than those of the women in the control group, and the values of α angle, MA, and CI of the women in group A and in group B were significantly higher than those of the women in the control group. The value of R of the women in group B were significantly lower than those in group A, and the values of CI and MA of the women in group B were significantly higher than those of the women in group A (all P<0.05). The values of R and C of the women had correlative with their values of PT, APTT, TT, and D-D (P<0.05), but which had no correlative with their FIB value (P>0.05). The K value of the women had correlative with their values of FIB and D-D (P<0.05), but which had no correlative with their PT, APTT, and TT values (P>0.05). The α angle value of the women had no correlative with their values of PT, APTT, TT, FIB, and D-D (P>0.05). The R value of the women with adverse pregnancy outcomes was significantly lower than that of the normal pregnant women, the CI and MA values of the women with adverse pregnancy outcomes were significantly higher than those of the normal pregnant women (P<0.05), and the values of K and α angle had no significant differences between the women with adverse pregnancy outcomes and the normal pregnant women (P>0.05). The R value, CI value, and MA value of the women all had certain predictive values for adverse pregnancy outcomes, and the areas under the curve of which for adverse pregnancy outcomes were 0.761, 0.739, and 0.733, respectively (P<0.001). Conclusion: TEG can effectively reflect the coagulation status of the pregnant women with PE，which has some predictive value for their adverse pregnancy outcomes.
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