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| Influence of serum glycocholic acid level and time of pregnancy termination of pregnant women with intrahepatic cholestasis of pregnancy on the outcomes of their perinatal infants |
| 1.The First Affiliated Hospital of the Air Force Military Medical University, Shaanxi Province, 710032；2. Air Force 986th Hospital；3.Shaanxi Provincial Rehabilitation Hospital |
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Abstract To investigate the influence of serum glycocholic acid（CG) level and time of pregnancy termination of pregnant women with intrahepatic cholestasis of pregnancy (ICP) on the outcomes of their perinatal infants. Methods: 112 pregnant women with ICP were selected in study group and 69 healthy pregnant women were selected in control group from July 2018 to July 2020. According to the serum CG level of the women in the study group, the women were divided into group A (63 women with low level CG of 2.7-13.5mg/L) and group B (49 women with high level CG of≥13.5mg/L). And according to the time of the pregnancy termination of the women in the study group, the women were also divided into group C (46 women with termination of pregnancy during <36 gestational weeks) and group D (466 women with termination of pregnancy during ≥36 gestational weeks). The serum CG level of all these women was detected by automatic biochemical analyzer. And the adverse outcomes of the perinatal infants were compared among these groups. The influencing factors of the adverse outcomes of the perinatal infants of the women with ICP were analyzed. Results: The levels of serum total bilirubin (TBIL) (14.79±3.36μmol/L), aspartate transaminase (AST) (65.61±4.63 U/L), alanine transaminase (ALT) (89.57±11.23 U/L), and CG (15.47±6.34 mg/L) of the women in the study group were significantly higher than those (6.37±2.83μmol/L, 15.27±2.82 U/L, 14.35±3.26 U/L, and 1.63±0.54 mg/L) of the women in the control group. The incidence of perinatal adverse outcomes of the women in group B was significantly higher than that of the women in group A, and which of the women in group C was
significantly higher than that of the women in group D (all P<0.05). Multivariate logistic regression analysis showed that the serum CG level ≥13.5mg/L (OR=2.16, 95%CI: 1.30-3.57) and the time of pregnancy termination <36 gestational weeks (OR=2.10, 95%CI= 1.29-3.42) of the women with ICP were the risk factors of the adverse outcomes of their perinatal infants (P<0.05). Conclusion: Abnormal high level of serum CG and the time of termination of pregnancy <36 gestational weeks of the pregnant women are closely related to the occurrence of the adverse outcomes of their perinatal infants, so it suggests that termination of pregnancy after 36 gestational weeks for the pregnant women with ICP can reduce the adverse outcomes of their perinatal infants.
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