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| Correlation between the expressions of serum thioredoxin interacting protein and glucose-regulated protein of pregnant women with gestational diabetes mellitus and their insulin resistance |
| 1.Beijing Road Medical District Branch, General Hospital of Xinjiang Military Region, Urumqi, Xinjiang Uygur Autonomous Region, 830000; 2.Xinjiang Nanshan Airport Hospital |
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Abstract To explore the correlation between the expressions of serum thioredoxin interacting protein (TXNIP) and glucoseregulated protein 78（GRP78) of pregnant women with gestational diabetes mellitus (GDM) and their insulin resistance (IR). Methods: 94 pregnant women diagnosed as GDM by oral glucose tolerance test（OGTT) were selected in study group, and 94 pregnant women with normal glucose tolerance（NGT) were selected in control group from November 2018 to April 2021. The age, the family history of diabetes, the fasting blood glucose（FBG) level, the pre-pregnancy body mass index（BMI) value, the fasting insulin（FINS) level, the homeostasis model insulin resistance index（HOMA-IR) value, and the gestational weeks, and other data of the women were compared between the two groups. Enzyme-linked immunosorbent assay（ELISA) was used to measure the levels of serum TXNIP and GRP78. Pearson method was used to analyze the correlation between the serum TXNIP and GRP78 levels of the women with GDM and their HOMA-IR value. Receiver operating characteristic（ROC) curve was used to evaluate the value of serum TXNIP and GRP78 levels for diagnosing GDM. The influencing factors of GDM occurrence was analyzed. Results: The levels of serum TXNIP, GRP78, FINS, and FBG, the HOMA-IR value, and the proportion of family history of diabetes of the women in the study group were significantly higher than those of the women in the control group (P<0.05). The serum TXNIP and GRP78 levels of the women in the study group were positively correlated with their HOMA-IR value (r=0.557, 0.584, P<0.05). The area under the curve (AUC) of serum TXNIP and GRP78 levels for diagnosing GDM were 0.883 and 0.892, and the cut-off values of which were 48.67 pg/mL and 174.22 pg/mL, respectively, the sensitivity of which were 87.2% and 88.3%, respectively, and the specificity of which were 77.7% and 76.6%, respectively. The AUC of the combined levels of TXNIP and GRP78 for diagnosing GDM was 0.950, and the sensitivity and specificity of which were 85.1% and 91.5%. Family history of diabetes, abnormal increase of HOMA-IR value, and the levels of TXNIP and GRP78 were the risk factors affecting the occurrence of GDM (95%CI 1.697-4.214, 1.572-3.622, 1.626-3.959, 1.572-3.723, P<0.05). Conclusion: The levels of serum TXNIP and GRP78 of the pregnant women with GDM are abnormally increase, which are related to the IR value of the women. The combined levels of TXNIP and GRP78 for diagnosing GDM has high value.
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