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| The correlation of blood flow spectrum parameters of venous catheter of pregnant women and inhibinA and Netrin-1 levels and their diagnostic values for fetal chromosomal abnormality |
| Daxing Teaching Hospital, Capital Medical University, Beijing, 102600 |
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Abstract To analyze the correlation between venous catheter blood flow spectrum parameters of pregnant women and their inhibinA and Netrin-1 levels, and to study the diagnostic value of the blood flow spectrum parameters and the levels of inhibinA and Netrin-1 of the women for their fetal chromosomal abnormality. Methods: A total of 100 pregnant women with suspected fetal chromosomal abnormalities who had accepted examination of color Doppler ultrasonography were selected from July 2018 to July 2020. According to the gold standard of fetal chromosomal karyotype analysis, 52 cases with confirmed fetal chromosomal abnormalities were selected in study group, and 48 cases without confirmed fetal chromosomal abnormalities were selected in control group. The values of venous catheter blood flow spectrum parameters, such as resistance index (RI), pulsatile index (PI), and S/a of the women were compared between the two groups. The correlation between the values of RI, PI, S/a of the women and their inhibinA and Netrin-1 levels was analyzed. The diagnostic value of the values of RI, PI, and S/A for fetal chromosomal abnormalities was also analyzed. Results: The values of RI, PI, and S/a of the women in the study group were significantly higher than those of the women in the control group, and which of the women with fetal chromosomal abnormality, nervous system abnormality, and heart abnormality had increased gradually. The expression levels of inhibinA and Netrin-1 of the women with fetal chromosomal abnormalities, nervous system abnormality, and heart abnormality had decreased gradually (all P<0.05). In the study group, the values of RI, PI, and S/a of the women were positively correlated with their different disease types, while the levels of inhibinA and Netrin-1 of the women were negatively correlated with their different disease types, the values of RI, PI, and S/a of the women were negatively correlated with their inhibinA and Netrin-1 levels (all P<0.05).The combined values of RI, PI, and S/a for diagnosing fetal chromosome abnormality was significantly higher than that RI value, PI value, or S/a value alone, the area under the curve and the sensitivity of which were 0.847 and 98.2%. Conclusion: Venous catheter blood flow spectrum parameters values and the levels of inhibinA and Netrin-1 of the pregnant women have some clinical diagnostic value for their fetal chromosomal abnormalities.
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