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| The change of the levels of serum troponin I and plasma brain natriuretic peptide, and the value of Tei index of neonates after neonatal asphyxia and their value for assessing the myocardial injury degree of neonates |
| Nanyang Children's Hospital of Integrated Traditional Chinese and Western Medicine, Nanyang, Henan Province, 473002 |
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Abstract To analyze the clinical value of the levels of serum troponin Ⅰ（CTn Ⅰ) and plasma brain natriuretic peptide（BNP) combined with the value of Tei index for assessing the myocardial injury degree of neonates after neonatal asphyxia. Methods: 86 neonates with myocardial injury after asphyxia were selected as study subjects from January 2018 to January 2021. According to the asphyxia degree, these neonates were divided into group A（48 neonates with mild asphyxia, Apgar score 4-7 points) and group B（38 neonates with severe asphyxia, Apgar score 0-3 points). Meanwhile, 30 normal full-term neonates without asphyxia were selected in group C. The levels of serum CTnI and plasma BNP of the neonates in the three groups were detected, and the Tei index of the neonates was measured by cardiac color Doppler ultrasound. The correlation among the CTnⅠlevel, BNP level, and Tei index value of the neonates was analyzed. The Receiver operating characteristic (ROC) curve was used to analyze the values of the CTnⅠlevel, BNP level, and Tei index of the neonates value for predicting their myocardial injury degree. Results: The CTnⅠlevel, BNP level, and the Tei index value of the neonates in group B, group A, and group C had decreased gradually, and which of the neonates in group A and group B after treatment had significantly decreased (all P<0.05). Spearman correlation analysis showed that the levels of serum CTn Ⅰ and plasma BNP of the neonates were positively correlated with their Tei index value (P<0.05). ROC curve analysis showed that the levels of serum CTnⅠand plasma BNP combined with Tei index value of the neonates after neonatal asphyxia for predicting the degree of their myocardial injury had the highest of sensitivity (94.3%) and the highest of area under curve (0.833) of the neonates (P<0.05). Conclusion: The serum CTnⅠlevel, the plasma BNP level, and the Tei index value of the neonates after neonatal asphyxia are correlation each other, all of them can be used to assess the neonatal myocardial injury and cardiac function after asphyxia, which provides reference for clinical treatment.
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