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| Association between FTO gene polymorphisms of pregnant women and their gestational diabetes mellitus occurrence：a meta-analysis |
| Jiangsu Health Development Research Center，National Health and Family Planning Commission Contraceptives Adverse Reaction Surveillance Center，Nanjing, Jiangsu Province, 210036 |
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Abstract To investigate the association between the fat mass and obesity (FTO) related gene polymorphisms in rs9939609 and rs8050136 sites of pregnant women and their gestational diabetes mellitus (GDM) occurrence. Methods：The literatures about the association between the FTO related gene polymorphisms in rs9939609 and rs8050136 sites of the pregnant women and their GDM occurrence were searched from databases, such as Pubmed，EMBASE，and Wanfang，and web of science. The literatures were screened according to inclusion and exclusion criteria. Odds ratio（OR) and 95%CI were used to assess the association between the FTO related gene polymorphisms in rs9939609 and rs8050136 sites of the pregnant women and their GDM occurrence by random or fixed-effect models. Results：A total of 11 literatures were included in this meta-analysis，which were 2364 women with GDM and 4425 healthy pregnant women. In the three models of FTO related gen polymorphisms in rs9939609 site, the OR of AA to TT was 1.53 (95%CI：1.22-1.91，Ph=0.164), the OR of AA to TT+AT was 1.43 (95%CI 1.17-1.74, Ph=0.500), and the OR of AA+AT to TT was OR=1.22 (95%CI 1.04-1.44，Ph=0.054). It was suggested that FTO gene polymorphism in RS9939609 site of the women was associated with their GDM susceptibility. The subgroup analysis was conducted according to the sample size of the studies and the genotyping method of the women in the observation group, which had showed that FTO related gene polymorphism in RS9939609 site were all associated with the GDM susceptibility when the sample size >150 cases, or grouping by RT-PCR and Taq- MAN. 5 models of FTO related gene polymorphism in RS8050136 site gene had no statistical significance. Conclusion：FTO gene polymorphisms in rs9939609 site of the pregnant women may be a susceptible polymorphic locus of their GDM occurrence，while FTO gene polymorphisms in rs8050136 site may not be associated with their GDM occurrence.
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