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| Research progress of Periostin in female reproductive system |
| 1. Clinical Medicine School of Jining Medical University, Shandong Province, 272067；2. Affiliated Hospital of Jining Medical University |
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Abstract Periostin is an extracellular matrix protein，which is expressed in many tissues and organs of the human body and participates in the physiological and pathological regulation of the body through a variety of cytokines and signal pathways. In recent years， Periostin has been confirmed to play an important role in the female reproductive system. In the endometrium，the expression of Periostin is regulated by ovarian steroid hormones, and it can be used as a marker of endometrial receptivity，which also plays an important role in the progression of embryonic implantation and pregnancy. Meanwhile, Periostin is involved in the regulation of endometriosis，and which is highly expressed in the patients with uterine fibroids and polycystic ovary syndrome. Periostin plays an important role in the invasion and the metastasis of endometrial，cervical, and ovarian cancers. This article reviews the studies related to the expression and role of Periostin in the female reproductive system and its influences on the pregnancy of female systematically.
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