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| Value of the homocysteine level combined with the pregnancy-associated plasma protein-A and human chorionic gonadotropin levels for predicting the treatment outcomes of women with early threatened abortion |
| Guang'an People's Hospital, Guang'an, Sichuan Province, 638000 |
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Abstract To analyze the value of the homocysteine (Hcy) level combined with the levels of pregnancy-associated plasma protein-A (PAPP-A) and human chorionic gonadotropin (HCG) for predicting the treatment outcomes of women with early threatened abortion. Methods: The clinical data of 135 pregnant women with early threatened abortion from July 2018 to June 2020 were analyzed retrospectively. According to the pregnancy outcomes, these women were divided into group A (72 cases with continued pregnancy) and group B (63 cases with inevitable abortion), and 60 normal pregnant women with regularly prenatal examination were selected in group C. The levels of serum Hcy, PAPP-A, and HCG of the women were compared among the three groups. The predictive value of the levels of serum Hcy, PAPP-A, and HCG for the outcomes of early threatened abortion after treatment was analyzed. Results: The level of serum Hcy of the women in group B, group A, and group C had decreased gradually, while the levels of serum PAPP-A and HCG of the women in group B, group A, and group C had increased gradually (all P＜0.05). The cut off values of serum Hcy level, PAPP-A level, and HCG level for predicting the inevitable abortion of the women with threatened abortion were 7.59μmol/l, 6.38 ng/ml, and 12561.82 U/l, respectively. The sensitivity (87.3%), the specificity (93.1%), the accuracy (90.4%), the positive predictive value (91.7%), and the negative predictive value (89.3%) of the combined detections of serum Hcy, PAPP-A, and HCG levels for predicting the inevitable abortion were all higher. Conclusion: the combined detection of serum Hcy, PAPP-A, and HCG levels of women with early threatened abortion can be used to predict their outcomes after treatment.
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