To study the factors affecting the effect of uterine artery occlusion combined with lesion removed for treating women with type I and II of scar pregnancy (SP). Methods: 105 women with type I and II SP from October 2016 to June 2020 were collected respectively. These women were divided into group A (60 women with uterine artery embolization combined with scar lesion removed) and group B (45 women with laparoscopic uterine artery ligation combined with scar lesion removed) according to the operative method and the treatment status of these women. And the women in the two groups were also divided into women with low risks of SP and women with high risks of SP according to the treatment mode of lesion. The preoperative indexes of the women were compared among these groups. And the possible factors affecting the operative effect were analyzed. Results: In group B and group A, there were all significant differences in the age, the time since last cesarean section, the days of menopause, the level of β-HCG before treatment, the maximum diameter of lesion, the muscle thickness of anterior wall of lesion, the vaginal bleeding situation during the first trimester of pregnancy, and the situations of SP, mass, and fetal heart beat examined by ultrasound between the women with low risks of SP and the women with high risks of SP (all P＜0.05). Multifactor analysis showed that the advanced age, the long time since last cesarean section, the short period of menopause, and the high β-HCG level before treatment of the women were the factors affecting the effect of embolization. The factors influencing the effect of ligation of the women were the advanced age, the long time since last cesarean section, the short period of menopause, the high level of β-HCG before treatment, the large lesion maximum diameter, the thin muscle of anterior wall of the lesion, the vaginal bleeding situation during the first trimester of pregnancy, and the situations of SP and fetal heart beat examined by ultrasound. Conclusion: It is suggested to select a reasonable surgical method for improving the operative effect based on analyzing the data of the women with type I and II SP before the operation of uterine artery embolization combined with lesion removed comprehensively.