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| Influence factors of intrauterine infection of pregnant women and the values of C-reactive protein and interleukin-6 levels, and vaginal group B streptococcus infection for predicting the intrauterine infection |
| Hangzhou Hospital of Traditional Chinese Medical, Zhejiang Province, 310007 |
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Abstract To investigate the situation of the levels of C-reactive protein (CRP) and interleukin-6 (IL-6), and vaginal group B streptococcus (GBS) infection of pregnant women, and to study the values of the levels of CRP and IL-6, and the vaginal GBS infection for predicting intrauterine infection (IAI) of these women. Methods: A total of 100 pregnant women from January 2021 to November 2021 were collected retrospectively. These women were selected and were divided into study group (women with IAI) and control group (women without IAI) according to the occurrence of IAI. The clinical data, the levels of CRP and IL-6, and vaginal GBS infection status of the women were compared between the two groups. The influencing factors of IAI, and the efficacy of the levels of CRP and IL-6, and vaginal GBS infection for predicting IAI were analyzed. Results: The proportions of age ≥30 years old, the prolongation of labor, the premature rupture of membranes, the levels of CRP and IL-6, and the positive rate of vaginal GBS infection of the women in the control group were significantly lower than those of the women in the study group. The independent risk factors of IAI of the pregnant women included age ≥30 years old, the prolonged labor, the premature rupture of membranes, the higher level of IL-6 and CRP, and the vaginal GBS infection. The area under the curve of the CRP level, the IL-6 level, and the GBS infection for predicting IAI of the women during pregnancy were 0.745, 0.678, and 0.731, respectively, with the sensitivity and the specificity >65.0%. Conclusion: Age, duration of labor course, premature rupture of membranes, CRP and IL-6 levels, and vaginal GBS infection are all factors affecting the occurrence of IAI of the pregnant women. The CRP level, the IL-6 level, and GBS of the pregnant women have certain predictive values for their IAI, which can be used as the indicators for evaluating IAI of the pregnant women.
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