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| Effect of domestic or imported estrogen ointments for treating postmenopausal women with atrophic vaginitis and their influences on the vaginal conditions and serum sex hormones levels of postmenopausal women |
| Nanxun District Lianshi People's Hospital, Huzhou, Zhejiang Province, 313013 |
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Abstract To explore the effect of domestic or imported estrogen ointments for treating postmenopausal women with atrophic vaginitis, and to study their influences on the vaginal conditions and serum sex hormones levels of the postmenopausal women. Methods: A total of 153 postmenopausal women with atrophic vaginitis were enrolled in this study between June 2019 and June 2020. According to different medication methods, these women were divided into study group (78 women were given domestic estrogen ointment) and control group (75 women were given imported estrogen ointment). The clinical curative effect after treatment of the women was observed and compared between the two groups. The scores of vaginal inflammation, the levels of inflammatory factors in vaginal secretions, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), the abnormal rate of vaginal micro-environment, and the levels of serum follicle stimulating hormone (FSH) and estradiol (E2) before and after treatment, and the occurrence of adverse reactions of the women during treatment were observed and compared between the two groups. Results：The vaginal inflammation score of the women in group A (1.90±0.88 points) or in group B (1.92±0.90 points) after treatment was significantly lower than that (6.69±1.02 points or 6.66±1.00 points) of the women before treatment, and the levels of TNF-α and IL-6 in vaginal secretions of the women in group A and B after treatment were significantly lower than those before treatment, and the quality of life score and the serum FSH and E2 levels of the women in group A and B after treatment were significantly higher than those before treatment (all P＜0.05), but which of the women all had no significant difference between the two groups (P＞0.05). During the treatment, there was no significant difference in the incidence of drug-related adverse reactions (7.7% vs.2.7%) of the women between the two groups (P＞0.05). Conclusion: The curative effect of domestic and imported estrogen ointments for treating the postmenopausal women with atrophic vaginitis is similar，and both of which can alleviate their vaginitis, and can improve the levels of their sex hormones and vaginal micro-environment status, without increasing the incidence of adverse reactions.
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| Cite this article: |
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ZHANG Ping. Effect of domestic or imported estrogen ointments for treating postmenopausal women with atrophic vaginitis and their influences on the vaginal conditions and serum sex hormones levels of postmenopausal women [J]. 中国计划生育学杂志, 2022, 30(4): 757-.
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| URL: |
| https://www.zgjhsyx.com/EN/ OR https://www.zgjhsyx.com/EN/Y2022/V30/I4/757 |
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