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| Efficacy of low-dose aspirin in adjuvant treatment of infertility women with polycystic ovary syndrome and its influence on the prethrombotic state and endometrial receptivity |
| 1. Qionghai Maternal and Child Care Hospital, Qionghai, Hainan Province, 571400；2.Qionghai People's Hospital, Hainan Province |
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Abstract To investigate the efficacy of low-dose aspirin in adjuvant treatment of infertility women with polycystic ovary syndrome (PCOS), and to study its influence on the prethrombotic state and endometrial receptivity of the women. Methods: 102 infertility women with PCOS were selected and were divided into group A and group B (51 cases in each group) randomly from June 2019 to June 2020. The women in group A were treated by low-dose aspirin combined with conventional treatment, and the women in group B were treated by conventional treatment only. Another 51 healthy women of childbearing age were selected in group C. The testosterone (T) level, the value of luteinizing hormone (LH)/ follicle stimulating hormone (FSH), and the values of coagulation related indexes, such as activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), fibrinogen (FIB), D-dimer (DD), tissue-type plasminogen activator ( t-PA), and plasminogen activator inhibitor-1 (PAI-1), of the women were compared among the three groups. The ovulation and pregnancy conditions, the endometrial thickness, the resistance index (RI) value, and the ratio of the value of end of systole to the end of diastole (S/D) of the maximum blood flow velocity of the uterine spiral artery by ultrasound of the women were compared between group A and group B. Results: The serum T level, and the values of LH/FSH, FIB, D-D, and PAI-1 of the women in group A and group B were significantly higher than those of the women in group C, and the values of serum APTT, PT, TT, and T-PA of the women in group A and group B were significantly lower than those of the women in group C (all P＜0.05). After treatment, the serum T level and LH/FSH value of the women in group A and group B had decreased significantly, and which of the women in group A were significantly lower than those of the women in group B. The values of endometrial thickness and S/D of the women in group A and group B had increased significantly, but the RI value of the women in group A and group B had decreased significantly, and the improvement degrees of which of the women in group A were significantly better than those of the women in group B. The values of FIB, D-D, and PAI-1 of the women in group A and group B had decreased significantly, but the values of APTT, PT, TT, and T-PA of the women in group A and group B had increased significantly, and the degrees of improvements of which of the women in group A were significantly better than those of the women in group B (all P＜0.05). In 1-year followed up, there was no significant difference in the ovulation rate (88.2% vs.84.3%) of the women between group A and group B (P＞0.05). The pregnancy rate (60.8%) of the women in group A was significantly higher than that (43.1%) of the women in group B, and the abortion rate (9.7%) of the women in group A was significantly lower than that (27.3%) of the women in group B (all P＜0.05). Conclusion: Low-dose aspirin for adjuvant treatment of the infertility women PCOS can relieve the prethrombotic state, improve endometrial capacity, and also can increase the pregnancy rate and reduce the risk of miscarriage of patients.
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