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Abstract To investigate the correlation between the degree of renal injury of pregnant women with hypertensive disorder complicating pregnancy (HDP) and their levels of urinary N-acetyl -β - D-glucosaminidase (NAG), neutrophil gelatinase associated lipocalin (NGAL), urinary retinol binding protein (RBP) and Microalbumin (mAlB). Methods: 132 pregnant women with HDP were selected in observation group from January 2020 to May 2021, which included 44 women with hypertension during pregnancy in group A, 35 women with mild preeclampsia in group B, 31 women with severe preeclampsia in group C, and 22 patients women with eclampsia in group D. Meanwhile, 100 normal pregnant women were selected in control group. The levels of urine NAG, NGAL, RBP, and mALB of the women in observation group and control group were examined, and color Doppler examination of kidney was also performed on these women. Results: The levels of urine NAG (18.82±3.40U/L), NGAL (36.60±8.11g/L), RBP (3.16±0.82mg/L), and mALB (67.83±19.29mg/L), and the acceleration time of blood flow parameters (AT, 88.95±12.21Ms) of the women in the observation group were significantly higher than those (9.15±1.43U/L, 13.02±3.43g/L, 0.50±0.11mg/L, 12.10±4.11mg/L, and 61.01±9.98ms) of the women in the control group (P＜0.05). The values of peak systolic velocity (PSV) (25.58±4.02cm/s), end diastolic velocity (EDV) (12.10±2.43cm/s), and systolic acceleration (SA) (1.70±0.34m/s) of the women in the observation group were significantly lower than those (40.42±5.17cm/s and 17.43±3.06cm/s) of the women in the control group. The levels of urine NAG, NGAL, RBP, mALB, and blood flow parameters AT of the women in group D were significantly higher than those of the women in group A, group B, or group C, but the values of PSV, EDV, and SA of the women in group D were significantly lower. In the observation group, the levels of NAG, NGAL, RBP, mALB and blood flow parameters AT of the women with renal injury were significantly higher than those of the women without renal injury (P＜0.05), while the values of PSV, EDV and SA of the women with renal injury were significantly lower (all P＜0.05). The NAG and NGAL levels were negatively correlated with the PSV and EDV values, while the NAG, NGAL, RBP, and mALB levels were positively correlated with the AT value (all P＜0.05). Conclusion: The elevated levels of urine NAG, NGAL, RBP, and mALB of the pregnant women with HDP are related to their degrees of HDP and renal injury, as well as are certain related to their hemodynamics of renal artery.
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