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| Levels of serum 25-hydroxyvitamin D3 and anti-Mullerian hormone of women relevant to their ovarian reactivity and their values for predicting the outcomes of these women after freeze-thaw embryo transfer |
| 1.Maternal and Child Health Care Hospital of Tanghe County, Henan Province, 473400; 2.The Second Affilited Hospital of Zhengzhou University |
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Abstract To explore the levels of serum 25-hydroxyvitamin D3 (25-(OH) D3) and anti-Mullerian hormone (AMH) of women relevant to their ovarian reactivity, and to study their values for predicting the outcomes of these women after freeze-thaw embryo transfer (FET). Methods：According to the ovarian reactivity of these women after ovulation induction by drugs during assisted reproduction, these women were divided into group A (32 women with low response of ovarian), group B (69 women with normal response of ovarian), and group C (38 women with high response of ovarian). The serum 25-(OH) D3 and AMH levels were compared among the three groups, and which relevant to the ovarian response of the women in the three groups was analyzed. According to pregnancy outcomes, these women were also divided into group D (56 cases) and group E (83 cases). The serum 25-(OH) D3 and AMH levels of the women were compared between group D and group E. The predictive value of the serum 25-(OH) D3 and AMH levels for pregnancy outcomes of the women after FET was explored. Results：With the increase of ovarian reactivity, the age, total amount of exogenous gonadotropin decrease, the number of days of exogenous gonadotropin stimulation, the number of eggs obtained, the number of mature eggs, and the number of high-quality embryos had increased, and the levels of serum 25(OH)D3 and AMH had increased significantly (all P＜0.05). The levels of the levels of serum 25(OH) D3 and AMH of the women were positively correlated with their ovarian reactivity, but were negatively correlated with their age (P＜0.05). The levels of 25(OH) D3 and AMH of the women in group D were significantly higher than those of the women in group E (P＜0.05). The area under the curve of the serum 25(OH)D3 level, the AMH level, or the combination of serum 25(OH)D3 level and the AMH level of the women for predicting their pregnancy outcomes after FET was 0.737, 0.817, or 0.838, respectively. The sensitivity of the serum 25(OH)D3 level, the AMH level, or the combination of serum 25(OH)D3 level and the AMH level of the women for predicting their pregnancy outcomes after FET was 53.6%, 94.6%, 96.4%, respectively. The specificity of the serum 25(OH)D3 level, the AMH level, or the combination of serum 25(OH)D3 level and the AMH level of the women for predicting their pregnancy outcomes after FET was 88.0%, 54.2%, 50.6%, respectively (P＜0.05). Conclusion: The levels of serum 25-(OH) D3 and AMH of the infertility women after FET are significantly correlated with their ovarian reactivity, and which will increases with the ovarian reactivity enhancing. The combination of serum 25(OH) D3 level and the AMH level of the women for predicting the pregnancy outcomes of the women after FET has high value.
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