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| Relationship between the serum PLGF and sFlt-1 levels of high-risk pregnant women during the first trimester of pregnancy and their preeclampsia occurrence and the predictive efficiency of the serum PLGF and sFlt-1 levels for preeclampsia |
| The First Central Hospital of Baoding, Hebei Province, 071000 |
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Abstract To analyze the value of the levels of serum placental growth factor (PLGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) of high-risk pregnant women during the first trimester of pregnancy for predicting their preeclampsia occurrence. Methods: The clinical data of 100 high-risk pregnant women who received regular antenatal care and delivery from January 2018 to January 2021 were collected retrospectively. These women were included 42 women with preeclampsia in observation group, and 58 women without preeclampsia in control group. The women in the observation group were further divided in group A (22 women with mild preeclampsia) and group B (20 women with severe preeclampsia) according to the severity of preeclampsia. The differences of the serum PLGF and sFlt1 levels of the women during the first trimester of pregnancy were compared among these groups. The values of the serum PLGF and sFlt-1 levels of the women for predicting their preeclampsia was analyzed. Results: There were significant differences in the serum PLGF level (38.69±9.62 pg/ml vs. 58.17±14.33 pg/ml) and the serum SFLT-1 level (1468.88±217.14 pg/ml vs. 998.62±148.37 pg/ml) of the women during the first trimester of pregnancy between the observation group and the control group. There were significant differences in the serum PLGF level (44.13±10.16 pg/ml vs. 25.89±7.12 pg/ml) and the serum SFLT-1 level (1228.49±175.55 pg/ml vs. 1802.60±246.10 pg/ml) of the women during the first trimester of pregnancy between group A and group B (P＜0.05). Pearson correlation analysis showed that the serum PLGF level of the women during the first trimester of pregnancy was negatively correlated with the severity of preeclampsia (r=-0.582, P＜0.05), and the serum SFLT-1 level of the women was positively correlated with the severity of preeclampsia (r=0.604, P＜0.05). When the optimal cut-off value of the PLGF level was 46.23 pg/ml, the AUC, the sensitivity and the specificity of the PLGF level for predicting preeclampsia of the high-risk pregnant women were 0.766, 78.9%, and 74.6%, respectively. When the optimal cut-off value of the sFlt-1 level was 1145.50 pg/ml, the AUC, the sensitivity, and the specificity of the sFlt-1 level for predicting preeclampsia of the high-risk pregnant women were 0.783, 80.02%, and 76.11%, respectively. The AUC, the sensitivity and the specificity of the combined of the levels of PLGF and sFlt-1 for predicting preeclampsia were 0.946, 91.2%, and 92.7%, respectively. Conclusion: The decrease of the serum PLGF level and the increase of the serum sFlt-1 level of the high-risk pregnant women may be related to their occurrence and progression of preeclampsia during the first trimester of pregnancy. Detections of serum PLGF and sFlt-1 levels of the high-risk pregnant women can be used as the reference indicators for predicting preeclampsia.
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