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| Influence of the indexes of blood coagulation and blood routine during the third trimester of pregnancy on their eclampsia occurrence and pregnancy outcomes |
| The First People's Hospital of Linping District, Hangzhou, Zhejiang Province, 311100 |
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Abstract To explore the influence of the indexes of blood coagulation and blood routine of pregnant women during the third trimester of pregnancy on their eclampsia occurrence and pregnancy outcomes. Methods: The clinical data of healthy pregnant women (in control group) and pregnant women patients with eclampsia (in study group) from 2015 to 2018 were selected as the research subjects. The differences of the indexes of blood coagulation and blood routine of the women were compared between the two groups. The correlation between the indexes of blood coagulation and blood routine of the women and their eclampsia occurrence was analyzed. The incidence of adverse pregnancy outcomes of the women with eclampsia was recorded. The relationship between the indexes of blood coagulation and blood routine of the women and their pregnancy outcomes was analyzed. Results: The values of plasma thrombin time (TT), prothrombin time (PT), activated prothrombin time (APTT), antithrombin Ⅲ (AT-Ⅲ) activity， and platelet (PLT) count of the women in the study group were significantly lower than those of the women in the control group, while the values of D-dimer, fibrinogen (FIB), and hematocrit (HCT) of the women in the study group were significantly higher (P＜0.05). There were no significant differences in the values of red blood cell count (RBC), white cell count (WBC), mean platelet volume (MPV), and hemoglobin concentration (Hb) of the women between the two groups (P＞0.05). Logistic multivariate analysis showed that the risk factors of eclampsia included D-dimer (OR=0.238), FIB (OR=0.368), and PLT count (OR=0.685) (all P＜0.05). The incidences of premature delivery, cesarean section, low birth weight, neonatal asphyxia, and perinatal mortality of the women had increased with the increase of the abnormal iteams of the indexes of blood coagulation and abnormal blood routine (P＜0.05). Conclusion: The indexes of blood coagulation and blood routine of the pregnant women are related to their eclampsia occurrence. The abnormal indexes of blood coagulation and blood routine of the pregnant women can lead to the adverse pregnancy outcomes, so which should be paid attention to in clinic.
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