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Abstract To analyze the effects of different visceral adiposity index (VAI) of patients with polycystic ovary syndrome (PCOS) on their sex hormone levels and insulin resistance. Methods: 239 patients with PCOS were selected as the research objects and were divided into VAI (Q1) group, VAI (Q2) group, VAI (Q3) group, and VAI (Q4) group according to the interquartile spacing of VAI level from February 2018 to July 2020. The levels of serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), total testosterone (T), sex hormone binding globulin (SHBG), triglycerides (TG), high-density lipoprotein (HDL), fasting plasma glucose (FPG), and fasting insulin (FINS) of the patients in the four groups were detected. The values of insulin resistance index (HOMA-IR) and insulin sensitive index (ISI), glucose area under the curve (GLU-AUC) of the patients in the four groups were calculated. The differences of sex hormone levels and insulin resistance indicators values of the patients were compared among these groups. The correlation between the VAI level of the patients and their sex hormone levels and insulin resistance indicators values were analyzed. The high risk factors of hyperandrogen and insulin resistance of the patients were also analyzed. Results: The serum T level of the patients in VAI (Q1) group, VAI (Q2) group, VAI (Q3) group, and VAI (Q4) group had increased gradually, while the SHBG level had decreased gradually (P＜0.05). The levels of serum FSH, LH and E2 of the patients had no significant different among VAI (Q1) group, VAI (Q2) group, VAI (Q3) group, and VAI (Q4) group (P＞0.05), but the HOMA-IR value of the patients in VAI (Q1) group, VAI (Q2) group, VAI (Q3) group, and VAI (Q4) group had increased gradually, the ISI value of the patients in VAI (Q1) group, VAI (Q2) group, VAI (Q3) group, and VAI (Q4) group had decreased gradually (P＜0.05). The levels of FPG, FINS, Glu-AUC, and INS-AUC of the patients in VAI (Q3) group and VAI (Q4) groups were significantly higher than those of the patients in VAI (Q1) group and VAI (Q2) group (P＜0.05). There were no significant differences in the levels of FPG, FINS, Glu-AUC, and INs-AUC of the patients between VAI (Q3) group and VAI (Q4) group, and between VAI (Q1) group and VAI (Q2) group (P＞0.05). The VAI value of the patients was positively correlated with their T level and HOMA-IR value (P＜0.05), but which was negatively correlated with their SHBG level and ISI value (P＜0.05), and which had no correlation with their FPG, FINS, Glu-AUC and INS-AUC levels (P＞0.05). The values of body mass index (BMI) and waist circumference (WC), and the values of VAI (the second quartile), VAI of the third quartile, and VAI of the fourth quartile were the independent risk factors of hyperandrogenemia (P＜0.05). Age, the values of BMI and WC, and the values of VAI (the second quartile), VAI (the third quartile), and VAI (the fourth quartile) were the independent risk factors of insulin resistance (P＜0.05). Conclusion: The patients with PCOS and increase of visceral fat are more likely to develop hyperandrogen and insulin resistance.
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