To analyze the application effect of different anaesthetic drugs and puncture interspace combined with target-oriented control of spinal anesthesia level during cesarean section of women with placenta previa complicating umbilical cord prolapse. Methods: 80 women with placenta previa complicating umbilical cord prolapse who wanted cesarean section were enrolled in this study from January 2017 to January 2021. These women were divided into two groups (40 cases in each group) by computer. All women received combined spinal epidural anesthesia (CSEA) during cesarean section. Anesthesia of the women in group A was induced at the L3-4 interspaces with 0.67% ropivacaine, and which of the women in group B was induced at L2-3 interspaces with 0.5% bupivacaine. The postural adjustments of the women in the two groups were designed to control the spinal anesthesia level. The anesthesia levels at the time of skin incision and the time of the fetal delivery of the women in the two groups were recorded. The intraoperative tractive situation and the rate of intraoperative hypotension of the women in the two groups were observed. Results: There were significant differences in anesthesia block level at the time of skin incision and the placenta delivery of the women between the two groups (P<0.05), but there was no significant difference in the epidural anesthesia dosage addition at the time of skin incision of the women between the two groups with anesthesia (P>0.05). The rate of the epidural anesthesia dosage addition (25.0%) of the women in group B at the time of placenta delivery was significantly higher than that (5.0%) of the women in group A (P<0.05). The incidence of tractive reaction (32.5%) of the women in group B at the time of placenta delivery was significantly higher than that (12.5%) of the women in group A (P<0.05). The incidences of hypotension (30.0% and 50.0%) of the women in group B at the time of skin incision and the time of placenta delivery were significantly higher than those (10.0% and 27.5%) of the women in group A (P<0.05). Conclusion: Application of target-oriented control of spinal anesthesia induced by 0.67% ropivacaine combined with postural adjustments during cesarean section of the women with placenta previa complicating umbilical cord prolapse can effectively control the anesthesia blockade level, and can reduce the rate of intraoperative hypotension, which has better effectiveness with good safety.