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| Research progress of epigenetics of selective intrauterine growth restriction in monochorionic twins |
| International Peace Maternity and Child Health Hospital Affiliated to School of Medicine, Shanghai Jiaotong University, Shanghai, 200030 |
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Abstract Selective intrauterine growth restriction (sIUGR) is one of the serious complications of monochorionic twins, which increases perinatal mortality and morbidity, and causes long-term neurodevelopment and cognitive impairment of newborns, but its molecular mechanism is still unclear. Epigenetics refers to the fact that gene expression or cell phenotypes can be heritable in some way without changing the DNA sequence. The latest researches have found that there are DNA methylation, non-coding RNA regulation, and histone modification in placental tissue of the fetuses with sIUGR. The change in the way of epigenetic regulation proves that the epigenetic regulation mechanism affects the growth and development of the placenta, and it participates in the pathogenesis of sIUGR. Therefore, exploring the epigenetic regulation mechanism related to sIUGR can provide new ideas for understanding the pathogenesis of sIUGR and determining clinical diagnosis and treatment strategies.
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