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| Effects of the intrauterine infection of premature infants on thelevels of their T-cell subsets, immunoglobulin, and inflammatory cytokines in peripheral blood |
| 1.Guangdong Medical University, Zhu Hai, Guangdong Province, 519000； 2.Zhu Hai Hospital of Integrated Traditional Chinese and Western Medicine；3.Affiliated Hospital of Guangdong Medical University |
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Abstract To investigate the effects of the intrauterine infection of premature infants on the levels of their T-cell subsets, immunoglobulin, and inflammatory cytokines in peripheral blood. Methods: 900 premature infants from January 2010 to January 2020 were analyzed retrospectively. The incidence of intrauterine infection of the premature infants was 13.6% (122 cases with intrauterine infection) and 778 cases without intrauterine infection. 122 cases with intrauterine infection were included in study group, 150 cases from 778 cases without intrauterine infection were randomly selected in control group. The levels of peripheral blood T cell subsets, immunoglobulin, and inflammatory factors of the premature infants in the 24th hour and the 7th day after birth were monitored. Results: In the 24th hour and the 7th day after birth, the levels of T cell subsets, the interleukin (IL)-1β, IL-6, IL-8, and the tumor necrosis factor (TNF-α) in peripheral blood of the premature infants in the study group were significantly higher than those of the premature infants in the control group, but the level of immunoglobulin of the premature infants in the study group was significantly lower (all P<0.05). Conclusion: The levels of T-cell subsets, immunoglobulin, and inflammatory cytokines in peripheral blood of the premature infants with intrauterine infection during pregnancy are abnormal, which has certain clinical significance for assessing the prognosis of the premature infants with intrauterine infection.
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