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Abstract To investigate the value of ultrasound monitoring the blood flow parameters of pregnant women and fetus, the serum vitamin D and placental growth factor (PLGF) levels for predicting the fetal growth restriction (FGR). Methods: 125 pregnant women with FGR from June 2018 to June 2021 were selected in study group retrospectively, and 125 normal pregnant women were selected in control group during the same period. All these women were monitored for the systolic/diastolic blood flow ratio (S/D), pulsatility index (PI), and resistance index (RI) of the artery (UA), middle cerebral artery (MCA), and uterine artery (UtA) by ultrasound during their 20-24 gestational weeks. The serum vitamin D and PLGF levels of these women were detected. Receiver operating characteristic (ROC) curve was used to evaluate the value of the indexes by ultrasound, and the serum vitamin D and PLGF levels for predicting FGR. Results: The values of S/D, PI, and RI of UA of the women in the study group were significantly higher than those of the women in the control group. The area under curve (AUC) of the value of S/D, PI, or RI for predicting FGR was 0.866, 0.817, and 0.849, respectively. The sensitivity of the value of S/D, PI, or RI for predicting FGR was 72.8%, 50.4%, and 72.8%, respectively. The specificity of the value of S/D, PI, or RI for predicting FGR was 91.2%, 100%, or 91.2%, respectively. The values of S/D, PI, and RI of MCA of the women in the study group were significantly lower than those of the women in the control group. The AUC of the value of S/D, PI, or RI for predicting FGR was 0.882, 0.869, or 0.834, respectively. The sensitivity of the value of S/D, PI, or RI for predicting FGR was 92.0%, 88.8%，or 90.4%, respectively. The specificity of the value of S/D, PI, or RI for predicting FGR was 74.4%，81.6%, or 72%, respectively. The values of S/D, PI, and RI of UtA of the women in the study group were significantly higher than those of the women in the control group. The AUC of the value of S/D, PI, or RI for predicting FGR was 0.866, 0.817, or 0.849, respectively. The sensitivity of the value of S/D, PI, or RI for predicting FGR was 91.2%，48%，or 48.8%, respectively. The specificity of the value of S/D, PI, or RI for predicting FGR was 52%, 90.4%，or 90.4%, respectively. The levels of D and PLGF of the women in the study group were significantly lower than those of the women in the control group. The AUC of the level of D or PLGF for predicting FGR was 54.4% or 99.2%, respectively. The sensitivity of the level of D or PLGF for predicting FGR was 54.4% or 99.2%. The specificity of the level of D or PLGF for predicting FGR was 91.2% or 52%. Conclusion: The blood flow parameters of UA, MCA, and UtA monitored ultrasound and the detection of the serum vitamin D and PLGF levels of the pregnant women during the second trimester of pregnancy have good value for predicting FGR. Comprehensive evaluation of the high risk pregnant women will reduce the FGR occurrence.
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