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Abstract To analyze the expression level and clinical significance of serum adipocytokines of pregnant women with different glucose tolerance during the second trimester of pregnancy. Methods: The clinical data of 180 pregnant women from January 2018 to October 2020 were collected. These women were divided into 58 women with gestational diabetes mellitus (GDM) in group A, 60 women with the impaired glucose tolerance (IGT)in group B, and 62 women with normal glucose tolerance (NGT) in group C according to the results of their 75g oral glucose tolerance test (75g OGTT) during 24-28 gestational weeks. The biochemical indicators of glycolipid metabolism value, and the levels of leptin, chemokine (CHEM), adiponectin (ADPN), fatty acid binding protein 4 (FABP-4), retinol binding protein 4 (RBP-4), Nesfatin-1, and adipokines of the pregnant women in the three groups were detected. Results: The levels of serum fasting blood-glucose (FPG), 1h blood glucose, 2h blood glucose, fasting insulin, and glycosylated hemoglobin, the values of insulin resistance index (HOMA-IR) and islet β cell index (HOMA-β), and the levels of serum LEP, CHEM, FABP-4, RBP-4, and NESfatin-1 of the women in group A, group B, and group C had decreased gradually, but the level of serum ADPN of the women in group A, group B, and group C had increased gradually (P<0.05). The serum levels of LEP, CHEM, FABP-4, RBP-4, and Nesfatin-1 of pregnant women during the second trimester of pregnancy were positively correlated with their HOMA-IR value, while the ADPN level of pregnant women was negatively correlated with their HOMA-IR value (all P<0.05). Conclusion: The serum adipocytokines level of the pregnant women with different glucose tolerance during the second trimester of pregnancy is different, which is closely related to their insulin resistance. The serum adipocytokines may be involved in the occurrence and progression of GDM, so the clinical detection of serum adipocytokines level of the women during the second trimester of pregnancy has some significance to assess their glucose tolerance.
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