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| Relationship between the levels of serum brain natriuretic peptide and microRNA-124 of pregnant women with preeclampsia and their condition of disease and pregnancy outcomes |
| The First People's Hospital of Shangqiu, Henan Province, 476000 |
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Abstract To explore the relationship between the levels of serum brain natriuretic peptide (BNP), microRNA-124 (miR-124) of pregnant women with preeclampsia (PE) and their condition of disease and pregnancy outcomes. Methods: A total of 132 pregnant women with PE were selected in study group and 60 healthy pregnant women were randomly selected in control group from June 2018 to June 2020. The women in the study group included 74 women with mild PE in group A and 58 women with severe PE in group B. The levels of serum BNP and miR-124, and the values of mean arterial pressure and quantitative 24-hour urine protein of the women were compared among these groups. The adverse pregnancy outcomes of all the women were analyzed. Logistic regression analysis was used to study the factors affecting adverse pregnancy outcomes of the women with PE. Results: The levels of BNP and miR-124, the values of mean arterial pressure and quantitative 24-hour urine protein of the women in the study group were significantly higher than those of the women in the control group, and which of the women in group B were significantly higher than those of the women in group A (all P<0.05). The incidence of adverse pregnancy outcomes of the women with high levels of BNP and Mir-124 had increased significantly (P<0.05). Multivariate analysis showed that the levels of serum BNP and miR-124, and the value of quantitative 24-hour urine protein were the independent risk factors affecting the adverse pregnancy outcomes of the women with PE (P<0.05). Conclusion: The levels of serum BNP and miR-124 of the pregnant women increase with the worsening of the disease, and the incidence of adverse pregnancy outcomes of the women with high levels of BNP and miR-124 is higher, which should be paid attention to in clinic.
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