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| Relationship between the levels of serum neuropilin-1 and neuropilin-2 of patients with endometriosis and their severity of endometriosis and infertility |
| 1. The Third Affiliated Hospital of Zhengzhou University, Henan Province, 450000；2. Zhengzhou Maternal and Child Health Care Hospital |
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Abstract To investigate the relationship between the levels of neuropilin-1 and neuropilin-2 in peripheral blood of patients with endometriosis (EMs) and their severity of EMs and infertility. Methods: 104 patients with EMs were selected in study group, and 104 healthy women of childbearing age were selected in control group from January 2016 to July 2017. The patients in the study group were further divided into group A (24 cases with EMs stage I), group B (22 cases with EMs stage II), group C (30 cases with EMs stage III), and group D (28 cases with EMs stage IV) according to the American Reproductive Society staging standard (R-AFS). The patients in the study group were further divided into group 1 (45 cases with infertility) and group 2 (59 cases without infertility). The serum neuropilin-1 and neuropilin-2 levels were determined by enzyme-linked immunoassay. Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of the serum neuropilin-1 and neuropilin-2 levels of the patients for their EMs and infertility occurrences. Multivariate logistic regression was used to analyze the related factors of infertility complicated with EMs of the patients. Results: There were no significant differences in age, diabetes mellitus history, hypertension history, and family tumor history of the patients between the study group and the control group (P>0.05). The levels of serum neuropilin-1 and neuropilin-2 of the patients in the study group were significantly higher than those of the patients in the control group, and which had increased with the aggravation of EMs. The levels of serum neuropilin-1 and neuropilin-2 of the patients in group 1 were significantly higher than those of the patients in group
2(all P<0.05). ROC curve analysis showed that the area under ROC curve of neuropilin-1 level and neuropilin-2 level for predicting EMs complicated with infertility was 0.82 (95%CI: 0.74-0.92) and 0.72 (95%CI: 0.63-0.81). When the optimal cut-off points of neuropilin-1 level was 27.02μg/L, the sensitivity and the specificity of neuropilin-1 level and NRP-2 level for predicting EMs complicated with infertility were 81.3% and81.7%. When the optimal cut-off points of neuropilin-1 level was 22.84μg/L, the sensitivity and the specificity of NRP-2 level for predicting complicated with infertility were 70.3% and 71.1%. The neuropilin-1 level >27.02μg/L and the neuropilin-2 level >22.84μg/L were the risk factors of EMs complicated with infertility (P<0.05). Conclusion: The abnormal increasing of the levels of serum neuropilin-1 and neuropilin-2 of the patients with EMs are positively correlated with their severity of EMs and infertility, which have certain predictive value for EMs complicated with infertility of the patients.
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