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| Changes and clinical significance of the levels of serum anti-sperm antibody and anticardiolipin antibody of infertile women |
| Guang'an Hospital, West China Hospital, Sichuan University, Guang'an, Sichuan Province, 638000 |
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Abstract To analyze the changes of and clinical significance of the levels of serum anti-sperm antibody (AsAb) and anticardiolipin antibody (ACAb) of infertile women, and to study their clinical significance. Methods: 400 infertile women were selected in study group and 100 normal women who received physical examination were selected in control group from July 2018 to June 2020. The levels of serum AsAb and ACAb of the women in the two groups were detected by enzyme-linked immunosorbent assay (ELISA). The differences of the serum AsAb and ACAb levels of the women were compared between the two groups. In the study group, the differences of the serum AsAb and ACAb levels were compared among the women with different types of infertility and among the women with different abortion histories. Results: The positive rates of AsAb (25.8%) and ACAb (27.0%) of the women in the study group were significantly higher than those (3.0% and 4.0%) of the women in the control group. The positive rates of AsAb and ACAb of the women with the secondary infertility were significantly higher than those of the women with the primary infertility. The positive rates of AsAb and ACAb of the women with once, 2, and ≥3 times of abortions had increased in turn (P<0.05). Conclusion: The levels of serum AsAb and ACAb of infertile women increase, and which of the women with different types of infertility and different frequencies of miscarriage are different. It indicates that the detection of serum AsAb and ACAb levels should be enhanced for providing references of clinical etiological diagnosis of infertility women.
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