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| Analysis of the affecting factors of residual/recurrence of cervical intraepithelial neoplasia after modified cold knife conization |
| Daxing District People's Hospital, Beijing, 102600 |
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Abstract To investigate the affecting factors of residual/recurrence of cervical intraepithelial neoplasia（CIN) after modified cold knife conization (CKC). Methods: The data from the medical records of 153 patients who underwent modified CKC from January 2019 to June 2020 were analyzed retrospectively, and all enrolled subjects had been followed up for 1 year. These patients were divided into two groups according to their postoperative residual/recurrence situation of CIN after modified CKC. The patients with residual/recurrence of CIN were in group A and the patients without residual/recurrence of CIN were in group B. Age, CIN involvement situation of cervical canal, CIN involvement quadrant of Cervix uteri, menopausal status, number of sexual partners, CIN glandular involvement status, CIN grade, preoperative human papillomavirus（HPV) infection, and postoperative HPV infection of the patients were compared between the two groups. Multifactorial logistic regression was used to analyze the factors influencing the residual/recurrence after CKC of CIN. Results: After the followed up for 1 year of 153 patients, there were 4 (2.6%) cases with postoperative residue of CIN, 12 (7.9%) cases with recurrence of CIN, and 137 (89.5%) cases without residue/recurrence of CIN. Univariate analysis showed that postoperative CIN residual/recurrence was associated with the age of the patients, and the situations of CIN cervical canal involvement, menopause, number of sexual partners, CIN involvement of cervical canal gland, CIN grade, preoperative and postoperative HPV infection of the patient (P＜0.05), but was not associated with the CIN involvement situation of cervical canal quadrant (P＞0.05). Conclusion: The corresponding preventive measures should be taken based on these independent risk factors of the residual/recurrence of CIN to improve the effect of modified CKC.
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