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| Analysis of the effect and the pregnancy outcomes of different dosages of levothyroxine for treating pregnant women with hypothyroidism |
| Fuzhou Maternal and Child Health Hospital, Fuzhou, Fujian Province, 350007 |
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Abstract To explore the clinical efficacy and the pregnancy outcomes of different dosages of levothyroxine for treating pregnant women with hypothyroidism. Methods: A total of 118 pregnant women with hypothyroidism were selected as the research subjects from March 2019 to December 2019. According to the required dosages of levothyroxine, these women were divided in group A (women treated with 50ug/d-75ug/d levothyroxine sodium tablets) and group B (women treated with 100ug/d-125ug/d levothyroxine sodium tablets). The treatment effect, the adverse reactions rate, and the pregnancy outcomes of the women in the two groups were observed. Results: After treatment, the levels of the thyroid function indexes, lipid metabolism indexes, and blood glucose metabolism indexes of the women in the two groups had improved significantly, and the improvement degree of which of the women in group B was significantly better than that of the women in group A (P＜0.05). During treatment, the incidence of adverse reactions (6.8%) of the women in group A was significantly lower than that (22.0%) of the women in group B, and the rate of adverse pregnancy outcomes (18.6%) of the women in group A was significantly higher than that (5.1%) of the women in group B (all P＜0.05). Conclusion: The use of high-dose levothyroxine sodium tablet for treating the pregnant women with hypothyroidism can significantly improve their thyroid function, relieve their abnormal glucose and lipid metabolism, promote their fetal development, and improve their pregnancy outcomes. However, high-dose levothyroxine sodium tablet is likely to increase the incidence of the adverse reactions of the women, so attention should be paid during treatment.
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