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| The changes of serum connective tissue growth factor and malignant tumor related substance group levels of the women with uterine fibroids after microwave ablation and the influence factor of recurrence |
| Chuzhou College of Clinical, Anhui Medical University / Chuzhou First People's Hospital, Chuzhou, Anhui Province, 239000 |
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Abstract To study the changes of serum connective tissue growth factor (CTGF) and malignant tumor related substance group（MTRSG) levels of the women with uterine fibroids after microwave ablation, and to analyze the influence factor of prognosis of uterine fibroids. Methods: The clinical data of 100 women with uterine fibroids who had received treatment from June 2018 to December 2019 were collected retrospectively. These women were divided into observation group (54 cases were given microwave ablation of uterine fibroids) and control group (46 cases were given laparoscopic myomectomy) according to the different surgical methods. The surgical indexes, the changes of serum CTGF and TSGF before and after surgery, and the occurrence of complications of the women were compared between the two groups. The influencing factors of uterine fibroids recurrence after surgery were analyzed. Results: The operation time, the blood loss, the defecation time, the exhaust time, and the bowel sound time of the women in the observation group were significantly less than those of the women in the control group (P＜0.05). The levels of CTGF (223.64±31.57 ng/ml) and MTRSG (53.49±4.65 U/ml) of the women in the observation group were significantly lower than those (336.57±46.37 ng/ml and 60.45±5.34 U/ml) of the women in the control group. The complication rate (3.7%) of the women in the observation group was significantly lower than that (26.1%) of the women in the control group (P＜0.05). Postoperative fibroid recurrence was positively correlated with the CTGF level (r=0.621, P=0.000) and the MTRSG level (r=0.327, P=0.001). The preoperative CTGF level was an independent risk factor of postoperative fibroid recurrence. Conclusion: Microwave ablation for treating uterine fibroids of the women has better effect than that of laparoscopic myomectomy, which can shorten the operation time and can reduce the complications rate. The levels of postoperative serum CTGF and MTRSG will improve, and the level of CTGF is an independent risk factor for the recurrence of uterine fibroids, so it should be paid attention to in clinic.
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