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| Expression and clinical significance of glucose transporter 1 and sulfate transferase 1A3 in uterine fibroids tissue |
| Yijishan Hospital, Wannan Medical College, Wuhu, Anhui Province，241001 |
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Abstract To explore the expression and clinical significance of glucose transporter 1（Glut-1) and sulfate transferase 1A3（SULT1A3) in uterine fibroids tissue. Methods: The uterine fibroids tissue specimens of 90 women after uterine myomectomy (in group A) and the myometrium tissue specimens of 78 women with uterine prolapse and without other uterine lesions after total hysterectomy (in group B) were collected between February 2019 and February 2021. Immunohistochemistry was used to detect the Glut-1 and SULT1A3 protein expressions in tissue samples. The relationship between the levels of Glut-1 protein and SULT1A3 protein of the women with uterine myomectomy and the clinicopathological characteristics of the women was analyzed. Kendall correlation analysis was used to analyze the correlation between the Glut-1 protein level and the SULT1A3 protein level. Results: The expression of Glut-1 protein in uterine fibroids tissues was significantly higher than that in normal myometrium tissues, but the expression of ULT1A3 protein in uterine fibroids tissues was significantly lower than that in normal myometrium tissues (all P<0.05). The Glut-1 and SULT1A3 proteins levels had showed no significant differences in the myometrium tissues among the women with different age, among the women with different body mass index, or among the women with different fibroid diameter (P>0.05). The expressions of Glut-1 protein and ULT1A3 protein in uterine fibroids tissues of the women with FIGO type 2 of uterine fibroids were higher (P<0.01). The expression of Glut-1 protein in uterine fibroids tissues of the women without menopause was high, and the expression of SULT1A3 protein in uterine fibroids tissues of the women with menopause was higher (P<0.05). Correlation analysis showed that the glut-1 protein level in uterine fibroids tissues was negatively correlated with the SULT1A3 protein level in uterine fibroids (P<0.01). Conclusion: The expression level of Glut-1 protein in uterine fibroids tissue is higher than that in normal myometrium tissues, while the expression level of SULT1A3 protein in uterine fibroids tissue is lower than that in normal myometrium tissues. Both of the expression levels of Glut-1 protein and SULT1A3 protein in uterine fibroids tissue of the women are related to their FIGO type of uterine fibroids and are related to their menopausal status, which are expected to become one of the new targets for treating uterine fibroids.
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