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Abstract To explore the levels and clinical significance of serum osteocalcin, β isomer of C-terminal telopeptide of type I collagen (β-CTX), calcium (Ca), phosphorus (P), and 25-hydroxyvitamin D (25(OH)D) of women with menopausal osteoporosis. Methods: A total of 257 women with menopausal osteoporosis or low bone mass confirmed by bone densitometer were enrolled between May and December 2020. According to different bone density, these women were divided into group A (68 cases with osteoporosis, T≤-2.5) and group B（124 cases with low bone mass, -2.5 <T<-1). 65 normal women (T≥-1) were selected in group C. The clinical data of the women in the three groups were collected. The levels of serum Ca, P, OC, β-CTX, and 25(OH)D of the women in the three groups were detected. The diagnostic value of all indexes for osteoporosis of women with menopausal osteoporosis was analyzed by receiver operating characteristic（ROC) curve. Results: There was no significant difference in the blood P level of the women among group A, group B, and group C (P>0.05). The serum Ca level of the women in group C, group B, and group A had decreased gradually (P<0.05). The OC and β-CTX levels of the women in group A were significantly higher than those of the women in group C, but the 25(OH)D level of the women in group A was significantly lower. The OC and β-CTX levels of the women in group B were significantly higher than those of the women in group C (all P<0.05). ROC curve analysis showed that the AUC of the level of serum Ca, OC, β-CTX, and 25(OH) D for diagnosing osteoporosis of menopausal women were 0.746, 0.774, 0.658, and 0.787, respectively, and the AUC of the combined of the levels of serum Ca, OC, β-CTX, and 25(OH) D for diagnosing osteoporosis of menopausal women was 0.902, which was the highest. Conclusion: The levels changes of serum Ca, OC, β-CTX, and 25(OH)D of women may be related to their occurrence of menopausal osteoporosis. The combined levels of serum Ca, OC, β-CTX, and 25(OH) D for diagnosing menopausal osteoporosis has high clinical value.
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