|
|
|
| Clinical significance of the vascular endothelial growth factor and Ki-67 expressions in endometrial tissue of infertility patients with endometrial polyps |
| General Hospital of Taiyuan Iron and Steel（Group) Co., Ltd. Taiyuan, Shanxi Province, 030003 |
|
|
|
|
Abstract To explore the clinical significance of the expressions of vascular endothelial growth factor（VEGF) and Ki-67 in endometrial tissue of the infertility patients with endometrial polyps. Methods: 90 infertility patients with endometrial polyps diagnosed by hysteroscope from June 2019 to January 2021 were collected in observation group. According to the history of polyps, these patients had included original onset of polyps and recurrence of polyps. According to the different situations of the endometrium, these patients were divided into group A (patients with proliferation period of the endometrium) and group B (patients with the implantation window period of the endometrium). 45 infertility patients without endometrial polyp were collected in control group. The polyps and surrounding tissues of the patients in the observation group and the endometrial tissue of the patients in the control group were collected for the VEGF and Ki-67 levels detected by immunohistochemical. The relative expressions of the VEGF and Ki-67 levels were analyzed. Results: The positive rates of VEGF protein in original onset of polyps tissues and recurrence of polyps tissues of the patients during proliferation period of the endometrium were 62.5% and 73.3%, and the positive rates of Ki-67 protein in original onset of polyps tissues and recurrence of polyps tissues of the patients in the observation group during proliferation period of the endometrium were 75.0% and 83.3%, which were all significantly higher than those in the surrounding tissues of polyps tissues of the patients in the observation group or those in the endometrial tissue tissues of the patients in the control group. The relative expression levels of VEGF protein and Ki-67 protein in original onset of polyps tissues and recurrence of polyps tissues of the patients in the observation group during proliferation period of the endometrium were significantly higher than those in the surrounding tissues of polyps of the patients in the observation group or those in the endometrial tissue of the patients in the control group (all P<0.05). In implantation window period of the endometrium, the positive rate (28.6%) of VEGF expression of the patients in the observation group was significantly lower than that (80.9%) of the patients in the control group (P<0.05), but there was no significant difference in the positive rate of ki-67 expression (10.7% vs.4.8%) of the patients between the observation group and the control group (P>0.05). Conclusion: In the proliferation period of the endometrium, the VEGF and Ki-67 expression levels of the patients are abnormally increase, which may be involved in the formation and recurrence of endometrial polyps. The low expression level of VEGF of the patients in the implantation window may be related to the poor endometrial receptivity, which can lead to infertility.
|
|
|
|
|
|
|
|
|
