To explore the effect of frozen-thawed embryo transfer（FET) or fresh embryo transfer for treating women on their clinical pregnancy rate and pregnancy outcomes during vitro fertilization and embryo transfer (IVF-ET). Methods: The clinical data of 473 women who accepted IVF-ET from January 2019-December 2019 were analyzed retrospectively. These women were divided into group A（327women with fresh embryo transfer) and group B (146 women with FET) according to different embryo transfer schemes. The basic data and pregnant situation of the women were compared between the two groups. Multivariate logistic regression was used to analyze the risk factors affecting the clinical pregnancy of the women with FET. Results: The total amount of gonadotropin (Gn) used of the women in group B was significantly less than that of the women in group A, the levels of estradiol (E2) and progesterone (P) on the human chorionic gonadotropin (hCG) day, the fertilization rate, the clinical pregnancy rate, and the incidence of macrosomia of the women in group B were significantly higher than those of the women in group A, but the incidence of ovarian hyperstimulation syndrome (OHSS), the endometrial thickness on the hCG day, and the total number of eggs obtained of the women in group B were significantly lower than those of the women in group A (all P<0.05). In group B, the total dosage of Gn used of the women with successful pregnancy was significantly less than that of the women with pregnancy failure, the levels of E2 and P on the hCG day, the fertilization rate, the endometrial thickness on the hCG day, and the total number of eggs obtained of the women with successful pregnancy were significantly higher than those of the women with pregnancy failure (all P<0.05). The levels of E2 and P, and the endometrial thickness thinned on the hCG day were the risk factors of clinical pregnancy of the women with FET (P<0.05). Conclusion: FET for treating women during IVF-ET can reduce the incidence of OHSS, and can obtain higher clinical pregnancy rate with better pregnancy outcomes, but which maybe increased the incidence of macrosomia.