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| The relationship between the levels of serum copeptin and galectin-3 of the pregnant women with hypertensive disorder complicating pregnancy and their decline of the left ventricular function |
| 1. Anhui Provincial Maternal and Child Health Care Hospital, Hefei, Anhui Province, 230001；2. School of Public Health of Anhui Medical University |
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Abstract To investigate the relationship between the levels of serum copeptin and galectin-3 of the pregnant women with hypertensive disorder complicating pregnancy (HDCP) and their decline of the left ventricular function. Methods: 150 pregnant women with HDCP were selected in observation group and were divided in group A (89 cases with HDCP) and group B (61 cases with preeclampsia) from June 2020 to May 2021. 100 normal pregnant women were selected in control group during the same period. The levels of serum peptide and galectin-3 of the women in the three groups were measured, and the indexes of left ventricular function were measured by ultrasound and were calculated. The basic data, the levels of serum peptide and galectin-3, the left ventricular function index of the women were compared among the three groups. Pearson correlation analysis and Logistic regression analysis were also performed. Results: The values of the systolic and diastolic blood pressure of the women in group B were significantly higher of the women in group A and in the control group (P＜0.05). The expression levels of serum copeptin and galectin-3, B-type natriuretic peptide (BNP), and lactate dehydrogenase (LDH) of the women in group B were significantly higher than those of the women in group A and in the control group (P＜0.05). The values of maximum early diastolic flow rate/maximum late diastolic velocity (E/A), and the early diastolic rapid filling fraction (RFF) of the women in group B were significantly lower than those of the women in group A and in the control group (P＜0.05). With the aggravation of HDCP, the expression levels of serum copeptin galectin-3, BNP, LDH of the women in group B were significantly higher than those of the women in group A. The serum copeptin and galectin-3 levels of the women with HDCP were no correlated with their cardiac output (CO), left ventricular ejection fraction (LVEF), and cardiac index (CI) values (P＞0.05), but were negatively correlated with their E/A and RFF values (P＜0.05). Logistic multifactor regression analysis showed that the serum copeptin and galectin-3, BNP, and LDH levels, and the values of systolic and diastolic blood pressure of the pregnant women with HDCP were the independent risk factors of their left ventricular diastolic function injury, which OR (95% CI) were 1.375 (1.209-1.566), 1.311 (1.122-1.535), 1.063 (1.021-1.107), 1.074 (1.033-1.115), 1042 (1.020-1.064), and 1.052(1.018-1.086), respectively. Conclusion: The levels of serum copeptin and galectin-3 of the pregnant women with HDCP are related to the severity of HDCP, both of which are the risk factors of the decline of the left ventricular function of these women and may be involved in the injury of left ventricular function of these women.
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