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| Study the role of glucose transporter protein l of pregnant women for the pathogenesis of their hypertensive disorder complicating pregnancy and preeclampsia |
| Shaanxi Provincial People's Hospital, Xi'an, Shaanxi Province, 710068 |
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Abstract To investigate the role of glucose transporter protein l (GLUT-1) of pregnant women for the pathogenesis of their hypertensive disorder complicating pregnancy (HDP) and preeclampsia. Methods: 110 pregnant women with HDP were enrolled in study group from April 2015 to September 2018, which included 22 women with HDP in group A, 48 cases with mild preeclampsia in group B, and 40 cases with severe preeclampsia in group C. Another 30 normal pregnant women who underwent antenatal examination were selected in control group during the same period. The expression levels of serum GLUT-1 and matrix metalloproteinase-2 (MMP-2) of the women were compared among these groups. The correlation between the serum GLUT-1 and MMP-2 levels of the women and their degree of HDP was analyzed. According to the random number table method, 88 women with preeclampsia were randomly divided into group D (44 women were given conventional treatment) and group E (44 women were given the released-controlled nifedipine treatment). The expression levels of serum GLUT-1, MMP-2, and 24h urinary protein, and the pregnancy outcomes of the women before and after 5 days of treatment were compared between the two groups. Results: The serum GLUT-1 and MMP-2 levels of the women in the control group, group A, group B, and group C had decreased successively (P<0.05), and there was a positive correlation between the serum GLUT-1 level and the serum MMP-2 level (r=0.583, P<0.05). After treatment, the serum GLUT-1 and MMP-2 levels of the women in group E were significantly higher than those of the women in group D, but 24 h urinary protein level of the women in group E was significantly lower (P<0.05). The gestational weeks when delivery and the neonatal weight of the women in group E were significantly higher than those of the women in group D (P<0.05). Conclusion: The level of GLUT-1 of the pregnant women with HDP abnormally decreases, which may be involved in the progression of HDP, and is related to influencing the invasion ability of trophoblast by down-regulation of MMP-2 expression. Nifedipine can effectively increase the levels of GLUT-1 and MMP-2 of the pregnant women with HDP, can reduce their urine protein level, can prolong gestational weeks when delivery, can increase the weight of the newborns.
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